{"id":"W2335019891","doi":"10.1021/bi200238g","title":"Positions of Polar Amino Acids Alter Interactions between Transmembrane Segments and Detergents","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Circular dichroism; Transmembrane protein; Tryptophan; Bilayer; Transmembrane domain; Lipid bilayer; Membrane protein; Biophysics; Peptide; Amino acid; Membrane; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003646238,0.0001514169,0.0001405991,0.00002807875,0.00005374681,0.000007036589,0.0001356046,0.0001377001,0.0001130064],"category_scores_gemma":[0.000008805167,0.0001454723,0.0000884816,0.00004914517,0.00009733843,0.000006163608,0.00005691787,0.00008303991,0.000002915051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006863903,"about_ca_system_score_gemma":0.00002882034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002296882,"about_ca_topic_score_gemma":0.000003508535,"domain_scores_codex":[0.9992486,0.00001566079,0.0002114988,0.0002695171,0.00008589428,0.0001687832],"domain_scores_gemma":[0.9994898,0.000004046966,0.00006984,0.0002769024,0.000050057,0.0001093455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003189057,0.0000591532,0.02876165,0.00005129728,0.00006689024,0.000001345978,0.00007061113,3.761167e-8,0.9700615,0.000001492194,0.00007859372,0.0008155336],"study_design_scores_gemma":[0.0003627705,0.00008532753,0.0255316,0.00001857805,0.00008751671,0.00002657237,0.00004389421,4.745713e-7,0.9731964,0.000006842355,0.0004905121,0.0001494782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980975,0.00009445705,0.0001444636,0.00001777683,0.000105418,0.00008548406,0.0002013047,0.000009861262,0.001243784],"genre_scores_gemma":[0.9980335,0.00003622076,0.0007954914,0.00004685467,0.0001964838,0.00001051469,0.0003002732,0.00001683583,0.0005638067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003230053,"threshold_uncertainty_score":0.5932189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685543276405551,"score_gpt":0.2586037870374192,"score_spread":0.2417483542733636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}