{"id":"W2335019891","doi":"10.1021/bi200238g","title":"Positions of Polar Amino Acids Alter Interactions between Transmembrane Segments and Detergents","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Circular dichroism; Transmembrane protein; Tryptophan; Bilayer; Transmembrane domain; Lipid bilayer; Membrane protein; Biophysics; Peptide; Amino acid; Membrane; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001270342,0.0003068033,0.0001554591,0.00008040864,0.0001199987,0.0002477355,0.0001486199,0.0002324906,0.0008317485],"category_scores_gemma":[0.0001940092,0.0001281153,0.0001280669,0.0001069861,0.0002737681,0.0001840799,0.0001992243,0.0003485584,0.0002667023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792129,"about_ca_system_score_gemma":0.0001508977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002941674,"about_ca_topic_score_gemma":0.0003447656,"domain_scores_codex":[0.9999062,0.00002856109,0.000008634089,0.00002118529,0.00001474892,0.00002073339],"domain_scores_gemma":[0.9998642,0.00004725167,0.00004045483,0.00001117822,0.00001044233,0.00002640749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001161323,0.00001335698,0.0001472926,0.0000148434,0.000003914208,0.0000436422,0.00001055279,0.00004558518,0.9992125,0.00007064088,0.000005795394,0.0003156119],"study_design_scores_gemma":[0.00000815258,0.0001239084,0.001470616,0.000003024307,0.0000116612,0.0001055639,0.00001993514,0.0002787223,0.9974211,0.00003139817,0.0005226386,0.000003174265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980208,0.0002867869,0.001061906,0.00003173386,0.00001097297,0.000007955704,0.0000406902,0.00001379448,0.0005254374],"genre_scores_gemma":[0.9982906,0.0002787025,0.0008688974,0.00003508158,0.000003810908,0.00000700191,0.00006157313,0.000009278448,0.0004449662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008317485,"threshold_uncertainty_score":0.002782464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685543276405551,"score_gpt":0.2586037870374192,"score_spread":0.2417483542733636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}