{"id":"W2335158018","doi":"10.1002/1873-3468.12143","title":"Glucosyl epi‐cyclophellitol allows mechanism‐based inactivation and structural analysis of human pancreatic α‐amylase","year":2016,"lang":"en","type":"letter","venue":"FEBS Letters","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institutes of Health; European Research Council; Canadian Institutes of Health Research; China Scholarship Council; U.S. Department of Energy","keywords":"Amylase; Mechanism (biology); Chemistry; Biochemistry; Computational biology; Biophysics; Enzyme; Biology; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009906452,0.0002975489,0.0004048181,0.0003073593,0.00008625659,0.00003080669,0.0001580466,0.0004172101,0.0001055907],"category_scores_gemma":[0.00003283792,0.0002613185,0.0001922866,0.0002071164,0.0000928169,0.00001002924,0.00004619411,0.000226711,0.00000261158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003636519,"about_ca_system_score_gemma":0.0000261449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002798576,"about_ca_topic_score_gemma":0.00000930119,"domain_scores_codex":[0.9984641,0.000139303,0.0003610439,0.0005728896,0.0002233381,0.0002393059],"domain_scores_gemma":[0.9989552,0.0000189692,0.0004050788,0.0004893073,0.0000890429,0.00004236237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002952746,0.000006112326,0.0006635924,0.00009322461,0.0005952877,0.000005873655,0.00002095155,0.00001375651,0.9693224,0.00001450349,0.02899609,0.0002386253],"study_design_scores_gemma":[0.0008220329,0.0001656484,0.004606581,0.0000723152,0.001404908,0.000005654031,0.000011451,0.000179191,0.9043542,0.00006539507,0.08765695,0.0006556415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8836616,0.00005206456,0.003623716,0.1119922,0.0002185457,0.0002578228,0.0001369039,0.00002047572,0.00003664739],"genre_scores_gemma":[0.7484459,0.00005699983,0.0003182526,0.2394832,0.002323433,0.00004698572,0.008630441,0.00006870608,0.0006260486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1352157,"threshold_uncertainty_score":0.9999839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043281830946263,"score_gpt":0.2335120560982767,"score_spread":0.2254687742673305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}