{"id":"W2335159862","doi":"10.1007/s00401-016-1574-9","title":"Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis","year":2016,"lang":"en","type":"letter","venue":"Acta Neuropathologica","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Medical Research Council; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"SMARCB1; Chordoma; Biology; Pathology; Medicine; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006047794,0.0008636733,0.001117557,0.0008773688,0.001109077,0.001588069,0.001198805,0.007789712,0.002002594],"category_scores_gemma":[0.005354312,0.0005254468,0.000649212,0.0007194696,0.001840797,0.001530765,0.000921326,0.005053039,0.001099823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001754462,"about_ca_system_score_gemma":0.000683932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009111666,"about_ca_topic_score_gemma":0.001240109,"domain_scores_codex":[0.9994897,0.00008416056,0.00005695631,0.0001041291,0.0001076174,0.0001575254],"domain_scores_gemma":[0.9984107,0.000569739,0.0002078443,0.0001532784,0.0001424073,0.0005159485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002419105,0.00002221411,0.00856438,0.00006729282,0.00001729004,0.9703596,0.00009298886,0.0001375275,0.002495335,0.001820324,0.01108464,0.005096548],"study_design_scores_gemma":[0.00008775973,0.00008634083,0.007267598,0.00003579785,0.00004424628,0.9765317,0.0001483086,0.001239194,0.001070866,0.002921792,0.01053816,0.0000282944],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5858566,0.01608001,0.006651551,0.3093408,0.02378991,0.0002585641,0.000922832,0.0006808431,0.05641894],"genre_scores_gemma":[0.9613369,0.002458153,0.001948533,0.01249397,0.01713768,0.0000402357,0.0001911266,0.00005442119,0.004338972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007789712,"threshold_uncertainty_score":0.01272959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00812429266514003,"score_gpt":0.2079436322415689,"score_spread":0.1998193395764288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}