{"id":"W2335233297","doi":"10.1158/1538-7445.am10-1467","title":"Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; Alethia Biotherapeutics (Canada)","funders":"","keywords":"DU145; Clusterin; Cancer research; Monoclonal antibody; In vivo; Epithelial–mesenchymal transition; Antibody; Cancer; Metastasis; Prostate cancer; In vitro; Cancer cell; Chemistry; Biology; Molecular biology; Immunology; Medicine; Apoptosis; Internal medicine; Biochemistry; LNCaP","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001488862,0.0002591412,0.0003476496,0.00033052,0.00051872,0.00009876251,0.0005326727,0.0002344523,0.002323461],"category_scores_gemma":[0.00009757178,0.0001885366,0.0001754774,0.0004423465,0.0006705784,0.00008808882,0.0002004494,0.001745216,0.0002381715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001764258,"about_ca_system_score_gemma":0.000447541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004781846,"about_ca_topic_score_gemma":0.0004794191,"domain_scores_codex":[0.9968795,0.0002191761,0.0003314484,0.000626307,0.001025206,0.0009183967],"domain_scores_gemma":[0.9979365,0.0002622713,0.00005977483,0.0009706971,0.0003316918,0.0004390097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006940991,0.0001997529,0.002669938,0.000112952,0.00006616777,0.0002469539,0.001473019,0.00005302183,0.9822614,0.0000788109,0.001424458,0.0107195],"study_design_scores_gemma":[0.005751483,0.001027071,0.798342,0.0006141702,0.0001409494,0.0004148743,0.001532502,0.0009652521,0.1349674,0.0009160951,0.0544752,0.0008529213],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816243,0.0003090575,0.0001029682,0.01223278,0.0005375005,0.001471716,0.0001239045,0.00008428533,0.003513463],"genre_scores_gemma":[0.995177,0.0001846991,0.00008026329,0.001799922,0.001191147,0.0004849146,0.00007391565,0.00007254332,0.0009355801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8472939,"threshold_uncertainty_score":0.9985886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1014247955327899,"score_gpt":0.4556428528162041,"score_spread":0.3542180572834142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}