{"id":"W2335233297","doi":"10.1158/1538-7445.am10-1467","title":"Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Clusterin in disease pathology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute; Alethia Biotherapeutics (Canada)","funders":"","keywords":"DU145; Clusterin; Cancer research; Monoclonal antibody; In vivo; Epithelial–mesenchymal transition; Antibody; Cancer; Metastasis; Prostate cancer; In vitro; Cancer cell; Chemistry; Biology; Molecular biology; Immunology; Medicine; Apoptosis; Internal medicine; Biochemistry; LNCaP","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702827,0.0006319375,0.0002413964,0.0002751372,0.0001272005,0.0001945913,0.0003999969,0.0003363996,0.003816861],"category_scores_gemma":[0.00006504014,0.0001250954,0.0002842111,0.0001637739,0.0001652938,0.0001334175,0.0001474928,0.0004747615,0.001135928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006750887,"about_ca_system_score_gemma":0.0004177383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002122302,"about_ca_topic_score_gemma":0.001474329,"domain_scores_codex":[0.9998676,0.00002000183,0.000007576743,0.00002848203,0.00004602336,0.00003035568],"domain_scores_gemma":[0.9999747,0.000002423004,0.000006920563,0.000002170724,0.000004898782,0.000008893715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002482818,0.0001060885,0.0001831494,0.00009600523,0.00001976089,0.00007365196,0.000008183949,0.0005800584,0.9928269,0.0002793527,0.0006041226,0.004974384],"study_design_scores_gemma":[0.0001325684,0.0007918862,0.001303198,0.00001023014,0.0000456492,0.0003618259,0.000006504077,0.003158652,0.9794633,0.00005005367,0.01467075,0.000005370064],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9539526,0.009362618,0.02007944,0.0006305132,0.0003548095,0.0003579419,0.001743113,0.0006410519,0.01287787],"genre_scores_gemma":[0.9724884,0.001765911,0.009576062,0.0001481737,0.00003373021,0.000111785,0.002345252,0.00004641506,0.01348439],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003816861,"threshold_uncertainty_score":0.01276869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1014247955327899,"score_gpt":0.4556428528162041,"score_spread":0.3542180572834142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}