{"id":"W2335362604","doi":"10.1021/jm901042m","title":"Selective Kv1.5 Blockers: Development of (<i>R</i>)-1-(Methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a Potential Treatment for Atrial Arrhythmia","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Atrial fibrillation; Chemistry; Effective refractory period; Anti-Arrhythmia Agents; Cardiology; Refractory period; Internal medicine; Blockade; Pharmacology; Refractory (planetary science); Antiarrhythmic agent; Adverse effect; Cardiac arrhythmia; Heart disease; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003461716,0.0004896445,0.0004129965,0.000320388,0.0001267431,0.0003326725,0.000501197,0.0004734227,0.00109901],"category_scores_gemma":[0.0001550442,0.0002092704,0.0002910336,0.0001628906,0.0002159439,0.0003890145,0.0002087236,0.0006465295,0.0004208395],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002755128,"about_ca_system_score_gemma":0.0004098069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004942609,"about_ca_topic_score_gemma":0.001144484,"domain_scores_codex":[0.9999171,0.00001531785,0.000007969254,0.00002011421,0.00001624158,0.00002323603],"domain_scores_gemma":[0.9999411,0.000005160926,0.0000160856,0.000003973105,0.00001007775,0.00002354864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008042569,0.0004820066,0.0003920469,0.0003404013,0.00004164823,0.0003228626,0.00005162585,0.0004433015,0.924613,0.001459244,0.0007968628,0.07025269],"study_design_scores_gemma":[0.001924028,0.01539145,0.005848424,0.0001107979,0.0002866201,0.002755714,0.00004841204,0.002890436,0.9334658,0.0005796088,0.03665435,0.00004443496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8777942,0.07978371,0.02668805,0.001353787,0.000368059,0.0005830082,0.0006351949,0.0004555971,0.01233833],"genre_scores_gemma":[0.9396914,0.03771672,0.01510442,0.0007562742,0.0001540446,0.0002285305,0.0008982383,0.00003098078,0.005419511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109901,"threshold_uncertainty_score":0.003676593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01333242130504486,"score_gpt":0.2999718770455462,"score_spread":0.2866394557405014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}