{"id":"W2335372520","doi":"10.1093/neuonc/nou255.35","title":"ET-35 * PACRITINIB: A NOVEL JAK/STAT INHIBITOR WITH TRANSLATIONAL RELEVANCE FOR GBM","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Hotchkiss Brain Institute; Ontario Brain Institute; University of Calgary","funders":"","keywords":"Ruxolitinib; STAT protein; Janus kinase; STAT3; JAK-STAT signaling pathway; stat; Cancer research; PTEN; Myelofibrosis; Medicine; Signal transduction; Biology; Pharmacology; PI3K/AKT/mTOR pathway; Oncology; Internal medicine; Tyrosine kinase; Receptor; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156204,0.0003607258,0.0003251859,0.0002890765,0.0001411391,0.0003811998,0.0002027715,0.0003187912,0.001710638],"category_scores_gemma":[0.00005955124,0.0001023563,0.0002208806,0.0002667122,0.0001602002,0.0002604724,0.0001363201,0.0008642433,0.000536004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003949561,"about_ca_system_score_gemma":0.0003518162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007750379,"about_ca_topic_score_gemma":0.002027437,"domain_scores_codex":[0.9999303,0.00001324307,0.000004984392,0.00001419095,0.00001794274,0.00001923491],"domain_scores_gemma":[0.9999779,0.000002921289,0.000004579697,0.000001872837,0.000002573118,0.00001011783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004926512,0.001422022,0.001534453,0.0005171002,0.00009810016,0.0005747402,0.00008038853,0.002862229,0.8477274,0.001735131,0.005903764,0.1326181],"study_design_scores_gemma":[0.004731184,0.02058911,0.02565837,0.00009084744,0.0003582001,0.006599413,0.00007709026,0.01152363,0.8125934,0.001010989,0.1166696,0.00009810929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596887,0.0230783,0.002743656,0.0013033,0.0002310595,0.0002780345,0.001557958,0.000390242,0.01072877],"genre_scores_gemma":[0.9745842,0.01000623,0.005112956,0.0009118915,0.0001031155,0.0001491707,0.002644263,0.00003098221,0.006457091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001710638,"threshold_uncertainty_score":0.005722582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02835647275960196,"score_gpt":0.3231796751110784,"score_spread":0.2948232023514765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}