{"id":"W2335421053","doi":"10.1158/1535-7163.targ-11-a95","title":"Abstract A95: The determination of the maximum tolerated dose (MTD) of MGCD265 on an intermittent schedule: Phase I study results (Study 265-102).","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame","funders":"","keywords":"Medicine; Adverse effect; Nausea; Pharmacodynamics; Pharmacokinetics; Tolerability; Internal medicine; Maximum tolerated dose; Pharmacology; Gastroenterology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001327333,0.001299918,0.001048598,0.0003964053,0.0003122092,0.000815828,0.0008760439,0.001206915,0.004104815],"category_scores_gemma":[0.0007909592,0.0004469527,0.000775254,0.0003255717,0.000759215,0.0005609251,0.00026823,0.002923979,0.0009484532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007795116,"about_ca_system_score_gemma":0.001347993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009971689,"about_ca_topic_score_gemma":0.001473371,"domain_scores_codex":[0.9996752,0.0001349536,0.00002054394,0.00006438942,0.00004250604,0.00006249724],"domain_scores_gemma":[0.9992933,0.0001303769,0.0001504616,0.0000604368,0.00003700937,0.0003283043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5954866,0.09418696,0.01044807,0.0009415597,0.001007179,0.0008743378,0.0004027181,0.007498301,0.1723705,0.0007376311,0.00814542,0.1079007],"study_design_scores_gemma":[0.2928658,0.6729344,0.01226528,0.00004491558,0.0002785144,0.0005427506,0.00005068203,0.002635372,0.01478463,0.000202527,0.003361,0.00003409039],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933214,0.0008186269,0.001015539,0.0001745795,0.00004806302,0.001829273,0.001148938,0.0001185023,0.001525012],"genre_scores_gemma":[0.9920854,0.0005176511,0.00198863,0.0003485635,0.00009318551,0.001197976,0.002173116,0.00003093698,0.001564567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004104815,"threshold_uncertainty_score":0.01373202,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08630945641426414,"score_gpt":0.3885174583793756,"score_spread":0.3022080019651114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}