{"id":"W2335432651","doi":"10.1021/bi5013782","title":"Ligand Recognition Specificity of Leukocyte Integrin α<sub>M</sub>β<sub>2</sub> (Mac-1, CD11b/CD18) and Its Functional Consequences","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Heart, Lung, and Blood Institute","keywords":"Phage display; Integrin alpha M; Peptide; Integrin; Peptide library; Cell adhesion; Binding selectivity; Binding site; Biology; CD18; Chemistry; Biochemistry; Peptide sequence; Receptor; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004639629,0.0002616012,0.0003757621,0.0001229761,0.00006853703,0.00003499527,0.000121937,0.0002993285,0.0000675893],"category_scores_gemma":[0.0009103248,0.0002459412,0.0001103531,0.0002915277,0.0004360133,0.00007462816,0.0001408092,0.0004674957,0.0001367545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002061299,"about_ca_system_score_gemma":0.0006512924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001310231,"about_ca_topic_score_gemma":0.000005670892,"domain_scores_codex":[0.9978276,0.00006020799,0.0004405162,0.0005501514,0.0007693346,0.0003521961],"domain_scores_gemma":[0.9982118,0.000136425,0.0001704127,0.0003094554,0.0006874314,0.0004845003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007225444,0.0001644996,0.0006400695,0.0003387477,0.00005709237,0.00009517359,0.00005901838,9.023451e-7,0.9868032,0.000005880975,0.004957282,0.006155577],"study_design_scores_gemma":[0.001635373,0.0002104521,0.001439983,0.0002764644,0.00005814482,0.0003317944,0.0003564368,0.0001019451,0.9948694,0.0001718044,0.000310985,0.0002372835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948891,0.001483114,0.00004374969,0.0004359615,0.000132855,0.0002850096,0.00006525986,0.00005691475,0.002608002],"genre_scores_gemma":[0.9982355,0.0006574157,0.0001128749,0.00009970336,0.000355702,0.00002670801,0.0002310725,0.00002983589,0.000251208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008066122,"threshold_uncertainty_score":0.9999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06603466669532845,"score_gpt":0.2814880266249437,"score_spread":0.2154533599296152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}