{"id":"W2335544039","doi":"10.1371/journal.pone.0152861","title":"Combined AKT and MEK Pathway Blockade in Pre-Clinical Models of Enzalutamide-Resistant Prostate Cancer","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Prostate Cancer Canada; Astex Pharmaceuticals; Canadian Urological Association; Gilead Sciences; AstraZeneca","keywords":"LNCaP; Protein kinase B; Prostate cancer; Enzalutamide; PTEN; Cancer research; Androgen receptor; PI3K/AKT/mTOR pathway; Growth inhibition; Cancer; Medicine; Cell growth; Chemistry; Biology; Signal transduction; Internal medicine; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003205774,0.0001334882,0.0005015997,0.0001044749,0.00002435974,0.000006439554,0.00006867402,0.00008888196,0.00008707929],"category_scores_gemma":[0.0001096336,0.00007895426,0.00004772202,0.0001394368,0.0002252374,0.00008656706,0.0000672879,0.0001489129,0.000005188039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009965726,"about_ca_system_score_gemma":0.0002794189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002575331,"about_ca_topic_score_gemma":0.0001310829,"domain_scores_codex":[0.9984658,0.00007740877,0.000436677,0.0003051956,0.0004044199,0.000310527],"domain_scores_gemma":[0.9991412,0.0001958109,0.00009039395,0.0002504755,0.0001420263,0.0001800491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01172241,0.006715525,0.3526124,0.0009713549,0.0008613314,0.0001288123,0.001419716,0.000002920059,0.6157644,0.0002097839,0.0001457541,0.009445556],"study_design_scores_gemma":[0.03163718,0.005228901,0.2045656,0.006011231,0.0004227097,0.000002210283,0.00009208832,0.001111827,0.7460818,0.004349491,0.0001257596,0.0003711832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928063,0.002531492,0.000003434063,0.003127358,0.00002039724,0.0009470094,0.000112063,0.00002657429,0.0004253954],"genre_scores_gemma":[0.9876708,0.005698688,0.000282193,0.00005710304,0.00004880322,0.0001702175,0.000008246647,0.00002385127,0.006040105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1480468,"threshold_uncertainty_score":0.3219661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09755513344111376,"score_gpt":0.3343937115182147,"score_spread":0.2368385780771009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}