{"id":"W2335610915","doi":"10.1021/jp311350r","title":"Binding Mechanism of Inositol Stereoisomers to Monomers and Aggregates of Aβ(16-22)","year":2013,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Mechanism (biology); Inositol; Chemistry; Monomer; Stereochemistry; Biophysics; Biochemistry; Philosophy; Organic chemistry; Biology; Receptor; Epistemology; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004799703,0.0002618086,0.0001640861,0.0001034396,0.0003330945,0.0002430261,0.0003427526,0.0002227576,0.00139819],"category_scores_gemma":[0.000159042,0.0001521469,0.0002187909,0.00006819397,0.0003253387,0.0002901022,0.0001415473,0.0003116415,0.0001429828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005025903,"about_ca_system_score_gemma":0.0004092636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006213897,"about_ca_topic_score_gemma":0.004950971,"domain_scores_codex":[0.9999688,0.000003160084,9.223771e-7,0.000006565335,0.000008468928,0.00001206799],"domain_scores_gemma":[0.9999527,0.00001362333,0.00001292692,0.000002386118,0.000007032629,0.00001140651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006763207,0.0003131346,0.005568194,0.0002346892,0.00009906669,0.00037376,0.0002766181,0.1619396,0.8158539,0.006544092,0.0006213961,0.007499222],"study_design_scores_gemma":[0.0002253758,0.001168126,0.007659219,0.0000227653,0.00009295795,0.0001991555,0.0003299513,0.627747,0.358851,0.001848904,0.001779021,0.00007655867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971125,0.0001189615,0.001450869,0.00003759893,0.000005253047,0.00001111735,0.00004292659,0.00002041962,0.00120041],"genre_scores_gemma":[0.9981067,0.0001888432,0.00118879,0.0000266106,0.000001619807,0.00001455494,0.00006973152,0.000009242687,0.0003938228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006213897,"threshold_uncertainty_score":0.01235545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01444647837500958,"score_gpt":0.2811836226001891,"score_spread":0.2667371442251795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}