{"id":"W2335616360","doi":"10.1139/cjpp-2013-0028","title":"Glucocorticoids downregulate systemic nitric oxide synthesis and counteract overexpression of hepatic heme oxygenase-1 during endotoxin tolerance","year":2013,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Heme oxygenase; Nitric oxide; Internal medicine; Downregulation and upregulation; Endocrinology; Lipopolysaccharide; Chemistry; Heme; Nitrite; Systemic administration; Dexamethasone; Oxygenase; Nitric oxide synthase; Corticosterone; Biology; Medicine; In vivo; Biochemistry; Enzyme; Nitrate","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009723207,0.0003391849,0.0003036211,0.0002086888,0.0001114535,0.0002449431,0.0001385043,0.0001977397,0.0005657511],"category_scores_gemma":[0.0001407395,0.00009376816,0.0001588116,0.0001107657,0.0003704279,0.0001639241,0.0001767622,0.0007026092,0.0001148672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261095,"about_ca_system_score_gemma":0.0002425173,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006349976,"about_ca_topic_score_gemma":0.001467997,"domain_scores_codex":[0.9998664,0.00001854031,0.0000107156,0.0000279407,0.00003270963,0.00004379036],"domain_scores_gemma":[0.9997733,0.00001684516,0.00008771212,0.00002522784,0.00002085471,0.00007605133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003731894,0.00002687035,0.0003887979,0.00002012368,0.00000318146,0.00005409248,0.00001439007,0.00002095177,0.9973043,0.00003822815,0.0000184685,0.001737303],"study_design_scores_gemma":[0.00006364455,0.00160687,0.03637417,0.00001531734,0.00003855138,0.0003128479,0.0001609297,0.0004163418,0.9591758,0.0001400023,0.001680929,0.00001449772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971281,0.001304349,0.0009189407,0.0001217818,0.00004301964,0.00001045371,0.00009050286,0.00005210453,0.0003308298],"genre_scores_gemma":[0.9977163,0.0005842212,0.0006384856,0.00005161137,0.0000154896,0.00001507065,0.000096285,0.000007823619,0.0008747808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006349976,"threshold_uncertainty_score":0.001892567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004784827164212849,"score_gpt":0.2148960160644194,"score_spread":0.2101111889002066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}