{"id":"W2335763148","doi":"10.1016/j.jalz.2012.05.1732","title":"P4‐031: Suppression of drebrin gene expression causes Alzheimer's‐like synapse loss in primary hippocampal neurons in culture","year":2012,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Dendritic spine; Synapse; Hippocampal formation; Cell biology; Neuroscience; Actin cytoskeleton; Biology; Postsynaptic potential; Downregulation and upregulation; Chemistry; Cytoskeleton; Receptor; Cell; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002103966,0.0005228469,0.0006071401,0.0003288967,0.0003762101,0.0003211945,0.0006106013,0.0005436323,0.003078073],"category_scores_gemma":[0.0001295204,0.000215319,0.0005613843,0.0004706561,0.0003263007,0.0002817476,0.0003218214,0.001296043,0.001803046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004938201,"about_ca_system_score_gemma":0.0003517713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002007935,"about_ca_topic_score_gemma":0.002113418,"domain_scores_codex":[0.9996816,0.00002105022,0.00004765765,0.00007108312,0.0001018669,0.00007676132],"domain_scores_gemma":[0.9998404,0.00002659017,0.00002901413,0.00002830293,0.00002467828,0.00005110635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001390958,0.00007485221,0.00004114409,0.00004430007,0.000005731747,0.00006454677,0.00001872941,0.00002797287,0.9989919,0.00003738631,0.0001181824,0.0004362349],"study_design_scores_gemma":[0.00004081076,0.0004221983,0.002600736,0.000007849443,0.00002367536,0.000186288,0.00003763721,0.0004229549,0.9933805,0.00004574356,0.002824337,0.000007127872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833485,0.002520253,0.003404447,0.0003117966,0.0001741663,0.0001139893,0.005546656,0.0003015484,0.004278611],"genre_scores_gemma":[0.9512273,0.003594006,0.006838553,0.0003204393,0.00006391903,0.0005453207,0.0134421,0.0001962733,0.02377216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003078073,"threshold_uncertainty_score":0.01029718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03023937197760537,"score_gpt":0.303323800530599,"score_spread":0.2730844285529937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}