{"id":"W2336100438","doi":"10.1093/neuonc/nov209.42","title":"CBIO-42DOWN REGULATION OF PYRUVATE DEHYDROGENASE ACTIVITY IS ESSENTIAL FOR CELL PROLIFERATION IN IDH1 MUTANT GLIOMA CELLS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Mutant; Pyruvate dehydrogenase complex; Glioma; IDH1; Isocitrate dehydrogenase; Chemistry; Cell growth; Cell biology; Biochemistry; Cell; Enzyme; Biology; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008640961,0.0003939228,0.0004750517,0.0002529882,0.0002063272,0.0003220749,0.000314405,0.000261501,0.001161804],"category_scores_gemma":[0.00007620073,0.0001413729,0.0003238746,0.0002798143,0.0001943347,0.0001322875,0.0002041815,0.0006019438,0.0005871027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003708243,"about_ca_system_score_gemma":0.000396981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003038453,"about_ca_topic_score_gemma":0.002995593,"domain_scores_codex":[0.999778,0.00001820797,0.00002752737,0.000043138,0.00007754294,0.0000555776],"domain_scores_gemma":[0.9998995,0.00001207729,0.00001874394,0.00001932807,0.00001471783,0.00003566815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053293,0.00004466325,0.0001247638,0.00002511079,0.000003377536,0.00005603844,0.00001369892,0.00003016303,0.9987267,0.00005762606,0.00006650136,0.0007460336],"study_design_scores_gemma":[0.00001478837,0.0002078225,0.003622484,0.000003399542,0.000009024237,0.000136344,0.00002699973,0.0005381124,0.992737,0.00002782892,0.002671962,0.000004233837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913864,0.001990272,0.001735113,0.0002321889,0.00009474626,0.00004424739,0.001399018,0.0002429919,0.002875067],"genre_scores_gemma":[0.9912794,0.0009674971,0.00190369,0.00008088425,0.00001171327,0.00008441586,0.001643282,0.00004762555,0.003981532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003038453,"threshold_uncertainty_score":0.006041586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01569037873649329,"score_gpt":0.2773302706529404,"score_spread":0.261639891916447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}