{"id":"W2336107107","doi":"10.1038/onc.2016.69","title":"Regulation of Numb isoform expression by activated ERK signaling","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Garron Family Cancer Centre; Canadian Institutes of Health Research; Sickkids Research Institute","keywords":"NUMB; Biology; Alternative splicing; Carcinogenesis; Signal transduction; Gene isoform; Signal transducing adaptor protein; Cell biology; Notch signaling pathway; RNA splicing; Exon; Cell fate determination; Genetics; Transcription factor; Cancer; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686391,0.0002256484,0.0001428709,0.0001867281,0.000295353,0.0004913862,0.0001862805,0.0001697374,0.002116066],"category_scores_gemma":[0.0001730808,0.0001236719,0.0002133885,0.0001368618,0.0002063042,0.0004223685,0.0002989472,0.0006004162,0.0004810033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004666634,"about_ca_system_score_gemma":0.0002212727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003157507,"about_ca_topic_score_gemma":0.0007427973,"domain_scores_codex":[0.9998567,0.00002257719,0.00001004502,0.00002799941,0.00003520594,0.00004754105],"domain_scores_gemma":[0.9999218,0.00001256103,0.00001754899,0.00001129277,0.00001274915,0.00002409949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003379495,0.00003565095,0.0003960299,0.0000392073,0.000005265275,0.0000708072,0.00002708795,0.00006964798,0.9952695,0.00111391,0.00009127636,0.002543695],"study_design_scores_gemma":[0.00003315212,0.00008084553,0.01293533,0.00001116439,0.00001054864,0.0002477199,0.00009326817,0.002327553,0.9793009,0.0004996991,0.004454257,0.000005556779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888251,0.00177486,0.002982794,0.000264049,0.00006687241,0.00001863663,0.0003783042,0.00005015328,0.00563927],"genre_scores_gemma":[0.9914682,0.000801028,0.002056736,0.00004920186,0.00001322004,0.00002370083,0.0004327107,0.00002020721,0.005135025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002116066,"threshold_uncertainty_score":0.007078886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002338964679109,"score_gpt":0.2650101061403347,"score_spread":0.2549867164935435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}