{"id":"W2336194186","doi":"10.1002/cmdc.201600185","title":"Inside Cover: Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)‐Resistant CML Lines While Circumventing Pharmacokinetic Liabilities (ChemMedChem 8/2016)","year":2016,"lang":"en","type":"paratext","venue":"ChemMedChem","topic":"Synthesis of Tetrazole Derivatives","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto","funders":"","keywords":"Imatinib; Tyrosine kinase; Myeloid leukemia; Tyrosine-kinase inhibitor; Pharmacology; Chemistry; Dasatinib; Imatinib mesylate; Cancer research; Medicine; Signal transduction; Biochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.0009086644,0.002355164,0.002684702,0.0007689871,0.0004201191,0.0003753049,0.002107796,0.001674573,0.009239855],"category_scores_gemma":[0.002156817,0.002300882,0.0007846844,0.000866463,0.0008535317,0.001041038,0.0007876559,0.002363506,0.00112952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001824817,"about_ca_system_score_gemma":0.00098287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002439925,"about_ca_topic_score_gemma":0.00002796036,"domain_scores_codex":[0.9896343,0.0002215448,0.002811444,0.003029975,0.001460794,0.002841953],"domain_scores_gemma":[0.9932296,0.00144604,0.00165451,0.002365399,0.0005217416,0.0007827427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003985891,0.000694869,0.0002840127,0.003842036,0.0002455598,0.0001577793,0.001532155,0.00002033895,0.9616549,0.00002133469,0.01725434,0.01389407],"study_design_scores_gemma":[0.002351751,0.0001016325,0.00004877348,0.005199708,0.000208811,0.00004679235,0.001280411,0.0001516167,0.9360319,0.0003025301,0.05173782,0.002538218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8645283,0.01569257,0.00003624615,0.001086951,0.001305542,0.0008081149,0.0009357914,0.0006130459,0.1149934],"genre_scores_gemma":[0.9470864,0.001794996,0.0005788776,0.0003141715,0.005457421,0.0006132292,0.001619944,0.0007712789,0.04176371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08255804,"threshold_uncertainty_score":0.9999381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518726236898913,"score_gpt":0.2716485980011013,"score_spread":0.2464613356321122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}