{"id":"W2336425722","doi":"10.1097/fpc.0000000000000178","title":"Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia","year":2015,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université du Québec; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research","keywords":"Familial hypercholesterolemia; Statin; Genotype; Internal medicine; Endocrinology; HMG-CoA reductase; Cholesterol; LDL receptor; Penetrance; Hydroxymethylglutaryl-CoA reductase; Biology; Medicine; Lipoprotein; Reductase; Genetics; Gene; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005205158,0.0005175997,0.0003914088,0.0004823039,0.0005727734,0.0003292986,0.0002763905,0.0005237972,0.002053491],"category_scores_gemma":[0.001243303,0.0001853395,0.0004438114,0.0006822047,0.0003827007,0.0001318482,0.0001740906,0.0003281044,0.0001747155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006160863,"about_ca_system_score_gemma":0.0006740096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07388801,"about_ca_topic_score_gemma":0.06914087,"domain_scores_codex":[0.9995629,0.000102696,0.00004055039,0.0001204786,0.0001051568,0.00006820938],"domain_scores_gemma":[0.9994764,0.0001344232,0.0001927252,0.00004564312,0.00006211537,0.00008877934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002100615,0.00004791111,0.9802787,0.00003030943,0.0002932986,0.0008191444,0.0003966204,0.0002065723,0.01031105,0.000122385,0.0001370458,0.005256256],"study_design_scores_gemma":[0.00003536378,0.0000817786,0.9978635,0.000007661788,0.00009679503,0.0006880143,0.00008285447,0.0004005005,0.0004559626,0.0000623169,0.0002189659,0.000006255349],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990742,0.0002523893,0.00009161402,0.00006294954,0.00000410989,0.000004409353,0.0001594565,0.000003939317,0.0003467793],"genre_scores_gemma":[0.9995651,0.00004991477,0.000103711,0.00001472071,0.000006701165,0.000002711666,0.00008061996,0.000001876128,0.000174685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07388801,"threshold_uncertainty_score":0.1469159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633470816293875,"score_gpt":0.2970567557859043,"score_spread":0.2607220476229655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}