{"id":"W2336425722","doi":"10.1097/fpc.0000000000000178","title":"Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia","year":2015,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université du Québec; McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research","keywords":"Familial hypercholesterolemia; Statin; Genotype; Internal medicine; Endocrinology; HMG-CoA reductase; Cholesterol; LDL receptor; Penetrance; Hydroxymethylglutaryl-CoA reductase; Biology; Medicine; Lipoprotein; Reductase; Genetics; Gene; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007105381,0.0001681305,0.0004471618,0.000156599,0.00001852099,0.00001750666,0.00005344095,0.00006068098,0.000002804363],"category_scores_gemma":[0.00006304216,0.000166512,0.00003388613,0.0000955924,0.00009891688,0.00003850787,0.0001039509,0.0001818202,8.751716e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004131878,"about_ca_system_score_gemma":0.00007130553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001811147,"about_ca_topic_score_gemma":0.0003582534,"domain_scores_codex":[0.9988868,0.00008932092,0.0003413338,0.0002971306,0.0001613401,0.0002241246],"domain_scores_gemma":[0.9994423,0.00006805453,0.00006737437,0.0001416807,0.0000649108,0.0002156776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004049946,0.0001776047,0.04713338,0.0001492416,0.0001326869,0.00002326689,0.006118864,0.001287525,0.09536201,0.000008915715,0.00001145193,0.8491901],"study_design_scores_gemma":[0.03611667,0.0009781517,0.7645494,0.0003453724,0.0004865228,0.00009343784,0.002562656,0.04923601,0.1339157,0.000549042,0.01046809,0.0006989338],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898236,0.009316891,0.0001116628,0.00006770727,0.00006017495,0.0004516497,0.00006020202,0.00000614867,0.0001019281],"genre_scores_gemma":[0.9938638,0.003768422,0.001923501,0.0001884333,0.0001928572,0.00001003725,0.00001173189,0.00002631215,0.00001488756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8484911,"threshold_uncertainty_score":0.6790161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633470816293875,"score_gpt":0.2970567557859043,"score_spread":0.2607220476229655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}