{"id":"W2336487821","doi":"10.1038/ni.3436","title":"Tumor-necrosis factor is a master of T cell exhaustion","year":2016,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Tumor necrosis factor alpha; Inflammation; Immunology; Dysfunctional family; Cytokine; Tumor necrosis factor α; Necrosis; Biology; Pathogen; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0001150464,0.0006125708,0.0009077064,0.0006012535,0.0001358499,0.00001844285,0.0005950304,0.006766118,0.02285632],"category_scores_gemma":[0.00008026623,0.0004776324,0.0004912409,0.0001701741,0.0003992715,0.0001718276,0.0001867687,0.006680964,0.005187492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776801,"about_ca_system_score_gemma":0.0001186277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000523874,"about_ca_topic_score_gemma":0.000001222347,"domain_scores_codex":[0.9972522,0.0003822116,0.0007893653,0.0007341897,0.00009375592,0.0007482739],"domain_scores_gemma":[0.9975052,0.0002964522,0.000888955,0.0009197936,0.000377794,0.00001180651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00021704,0.0000339176,0.00002997704,0.0000646547,0.0003082554,0.00001241366,0.00009157968,9.344295e-9,0.4206223,0.00001431878,0.5776237,0.0009819446],"study_design_scores_gemma":[0.0009584673,0.0002549473,0.0002511954,0.0001108976,0.00008074137,0.0001252816,0.0000221893,9.604872e-8,0.3610757,0.0000435732,0.6367735,0.0003034368],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.04728236,0.05009148,0.0003991633,0.7142405,0.1434797,0.002336856,0.001404421,0.0007964743,0.03996905],"genre_scores_gemma":[0.09616609,0.0007417884,0.00005175779,0.5059319,0.001368098,0.00008508197,0.001794725,0.0001803646,0.3936802],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.3537111,"threshold_uncertainty_score":0.9997675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0095419994570989,"score_gpt":0.2211144044335219,"score_spread":0.211572404976423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}