{"id":"W2336489280","doi":"10.1016/j.bpj.2015.11.714","title":"Thermodynamics of Calcium Binding to Zebrafish Troponin C (TnC) Visualized through Isothermal Titration Calorimetry (ITC) and Molecular Dynamics (MD)","year":2016,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Child and Family Research Institute; Simon Fraser University","funders":"","keywords":"Isothermal titration calorimetry; Troponin C; Biophysics; Chemistry; Molecular dynamics; Gibbs free energy; Endothermic process; Zebrafish; Calcium; Umbrella sampling; Contractility; Crystallography; Biochemistry; Troponin; Biology; Thermodynamics; Gene; Physical chemistry; Computational chemistry; Physics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003746108,0.000309358,0.0002734864,0.0001834743,0.0004656299,0.0003093079,0.0006234061,0.0002924739,0.003439274],"category_scores_gemma":[0.0009914681,0.0002981565,0.0002282084,0.0001961969,0.0007449982,0.0004463764,0.0002434558,0.000891777,0.0003209898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001726578,"about_ca_system_score_gemma":0.0007399924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01757334,"about_ca_topic_score_gemma":0.01875013,"domain_scores_codex":[0.999815,0.00001424102,0.000006474424,0.00004953291,0.00006542548,0.00004935565],"domain_scores_gemma":[0.9997918,0.00008371475,0.00003493946,0.00001498682,0.00004154093,0.00003297022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003950409,0.00007347704,0.003532025,0.000111805,0.00003036037,0.00008169952,0.0001614294,0.005524351,0.9848269,0.001253413,0.0006951045,0.003314356],"study_design_scores_gemma":[0.00007754297,0.0003951983,0.03907769,0.00002473317,0.00003777806,0.0001068914,0.0001646948,0.07671412,0.8799803,0.0008596443,0.002451557,0.000109805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961958,0.0001902846,0.001411163,0.00008997801,0.00001717444,0.00001357087,0.0002938645,0.00004825623,0.001739939],"genre_scores_gemma":[0.9984239,0.0001014115,0.0005845659,0.00002736294,0.000004206893,0.00001715521,0.0001944522,0.0000195193,0.0006275089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01757334,"threshold_uncertainty_score":0.03494215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01473945832813453,"score_gpt":0.2655697404617817,"score_spread":0.2508302821336472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}