{"id":"W2336592170","doi":"10.3389/fimmu.2016.00137","title":"NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways","year":2016,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Lakehead University; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; Cystic Fibrosis Canada","keywords":"Alternative complement pathway; Complement (music); Complement system; Classical complement pathway; Bacteria; Computational biology; Biology; Chemistry; Microbiology; Immunology; Immune system; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002383081,0.0004808409,0.0007243645,0.0004020246,0.0002476232,0.00002840902,0.0003362568,0.0002735297,0.0001564717],"category_scores_gemma":[0.0000257009,0.0003310004,0.0000663626,0.0001233375,0.0007133796,0.0002481684,0.0003403415,0.0004303977,0.00004630363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001791696,"about_ca_system_score_gemma":0.00003627223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001263613,"about_ca_topic_score_gemma":0.00001662205,"domain_scores_codex":[0.9974568,0.0005119385,0.0004456152,0.000787815,0.00004709823,0.0007506933],"domain_scores_gemma":[0.9990361,0.0001973599,0.0002708263,0.0003951312,0.00005327099,0.00004732276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009394506,0.0001123921,0.002158947,0.000006361161,0.0004444644,0.00003483905,0.001326141,0.000001521487,0.9309315,0.00202782,0.000483675,0.06153286],"study_design_scores_gemma":[0.00687069,0.001887475,0.04546219,0.0002235476,0.00003279814,0.00009394497,0.0007536101,0.00002559894,0.9166173,0.01218817,0.01522001,0.0006246627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837146,0.001279477,0.01025299,0.000853885,0.002886776,0.0005645987,0.0001220526,0.00005049875,0.0002750748],"genre_scores_gemma":[0.9968608,0.001312088,0.0008988978,0.0004837305,0.00007254713,0.00006961192,0.00005318311,0.00004542726,0.0002037176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0609082,"threshold_uncertainty_score":0.9999142,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479146186073424,"score_gpt":0.2172819491815317,"score_spread":0.2024904873207975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}