{"id":"W2336831152","doi":"10.1016/j.cmet.2016.03.006","title":"Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy","year":2016,"lang":"en","type":"letter","venue":"Cell Metabolism","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Metformin; Medicine; Scopus; Cancer; Internal medicine; AMPK; Diabetes mellitus; Insulin; Type 2 diabetes; Insulin resistance; Oncology; Endocrinology; Pharmacology; Cancer research; MEDLINE; Chemistry; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001653915,0.0003463106,0.0008333379,0.0002196428,0.0003846364,0.001124269,0.0004625041,0.007174341,0.002271763],"category_scores_gemma":[0.00449703,0.0001838959,0.0005789936,0.0002420717,0.0009930488,0.0009600794,0.0003338353,0.007899911,0.001299101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001388332,"about_ca_system_score_gemma":0.000448366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003178083,"about_ca_topic_score_gemma":0.0004875984,"domain_scores_codex":[0.999477,0.0002191723,0.00005417115,0.00006471356,0.0001395298,0.00004545609],"domain_scores_gemma":[0.9982259,0.001160797,0.0002003097,0.0001264,0.0001286918,0.0001579944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005177002,0.0005802716,0.00824746,0.0004948074,0.0001765641,0.02028699,0.0002065766,0.001815972,0.0306454,0.03072402,0.6468171,0.2548277],"study_design_scores_gemma":[0.001716351,0.001955513,0.006994645,0.0004088659,0.0002419806,0.01737118,0.0002211215,0.004997715,0.01887507,0.06185247,0.8852038,0.0001613424],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01414507,0.01373936,0.002643007,0.9450513,0.01626923,0.00003643368,0.0002277335,0.0001701191,0.007717742],"genre_scores_gemma":[0.2372767,0.03855399,0.005667014,0.5766966,0.1171883,0.0002134568,0.0002388702,0.0001804695,0.02398463],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.007174341,"threshold_uncertainty_score":0.01007307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557761191178879,"score_gpt":0.2950747750439399,"score_spread":0.2694971631321511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}