{"id":"W2336857274","doi":"10.1021/acschemneuro.6b00041","title":"Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Eye Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; National Institutes of Health; Nova Scotia Health Research Foundation","keywords":"Allosteric regulation; Chemistry; Cannabinoid receptor; Cannabinoid; Binding site; Signal transduction; Receptor; Pharmacology; Computational biology; Biochemistry; Biology; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097754,0.0003409599,0.0002289099,0.0001723114,0.0001248945,0.0001881893,0.0003020934,0.0001944164,0.0008834747],"category_scores_gemma":[0.0001223307,0.0001009865,0.0001751036,0.0002022094,0.0002386898,0.0001467482,0.0001754745,0.0003537142,0.000356309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003369756,"about_ca_system_score_gemma":0.0002656405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009550137,"about_ca_topic_score_gemma":0.002262612,"domain_scores_codex":[0.9999217,0.000008467658,0.00000453465,0.00001944038,0.00002552448,0.00002040418],"domain_scores_gemma":[0.9999619,0.000007824317,0.00001054775,0.000005642409,0.000005445495,0.000008689106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005228995,0.00001623639,0.0000777922,0.00002301371,0.000002239717,0.00003225142,0.00000917428,0.0002653986,0.9968105,0.00009161021,0.00002440371,0.002595073],"study_design_scores_gemma":[0.000009406654,0.0002890864,0.0007775177,0.000002639892,0.000009666089,0.0001984001,0.00001470328,0.0007311347,0.9965192,0.00003771971,0.001406031,0.000004504813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986635,0.001274823,0.007643573,0.0001040924,0.000009800099,0.00008553316,0.0004968074,0.0001480534,0.003602375],"genre_scores_gemma":[0.9913108,0.001371591,0.004999989,0.0000806788,0.000003306008,0.00002934951,0.0004820582,0.00003565408,0.001686551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009550137,"threshold_uncertainty_score":0.002955496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032242414172852,"score_gpt":0.2804482760508368,"score_spread":0.2601258519091083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}