{"id":"W2336857274","doi":"10.1021/acschemneuro.6b00041","title":"Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe","year":2016,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Eye Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; National Institutes of Health; Nova Scotia Health Research Foundation","keywords":"Allosteric regulation; Chemistry; Cannabinoid receptor; Cannabinoid; Binding site; Signal transduction; Receptor; Pharmacology; Computational biology; Biochemistry; Biology; Agonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719381,0.0001839563,0.0003045232,0.0001568702,0.00009588096,0.00004640455,0.0001632432,0.00009187273,0.00002273723],"category_scores_gemma":[0.00134161,0.0001282793,0.00005635693,0.0004436356,0.0009420445,0.0001804304,0.0003440312,0.0001933936,0.000003084404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005095046,"about_ca_system_score_gemma":0.0001279669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001728307,"about_ca_topic_score_gemma":2.517167e-7,"domain_scores_codex":[0.9979878,0.00003125968,0.0003059802,0.0006334256,0.0005103386,0.0005311712],"domain_scores_gemma":[0.9990786,0.00005322287,0.00007164065,0.0002400466,0.0001561183,0.0004003645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006764493,0.0000848414,0.001782146,0.0002556946,0.000002281983,0.00005314176,0.000108312,5.250397e-8,0.9933769,0.00004429116,0.0004014673,0.003823293],"study_design_scores_gemma":[0.0007706597,0.0003102887,0.002039635,0.0003643602,0.00001649242,0.000317663,0.00006174698,0.0001237937,0.9945099,0.00001980896,0.001286987,0.0001786953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913145,0.0001255663,0.00090923,0.007085821,0.00007836067,0.0003773151,0.00003611911,0.00002581259,0.00004725706],"genre_scores_gemma":[0.9973166,0.00004694553,0.00140435,0.0004641601,0.0000367067,0.00003445584,0.000002033669,0.00002190013,0.0006728307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006621661,"threshold_uncertainty_score":0.5231076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02032242414172852,"score_gpt":0.2804482760508368,"score_spread":0.2601258519091083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}