{"id":"W2336940083","doi":"10.1021/acs.analchem.6b00707","title":"Initial Diagnosis of <i>ALK</i>-Positive Non-Small-Cell Lung Cancer Based on Analysis of <i>ALK</i> Status Utilizing Droplet Digital PCR","year":2016,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Genome British Columbia","keywords":"Anaplastic lymphoma kinase; Chemistry; Digital polymerase chain reaction; Fusion gene; Molecular biology; Fluorescence in situ hybridization; Cancer research; Crizotinib; Lung cancer; Chromosomal translocation; ALK inhibitor; Gene; Polymerase chain reaction; Chromosome; Biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003308806,0.0004053942,0.0004446499,0.0007933197,0.0001863572,0.0004388662,0.000297254,0.0006411028,0.0009651809],"category_scores_gemma":[0.0008199786,0.0002097827,0.0002069619,0.000225821,0.0003513406,0.0003992504,0.0002656289,0.0005491402,0.0005697572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798441,"about_ca_system_score_gemma":0.000271602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006291646,"about_ca_topic_score_gemma":0.0009826921,"domain_scores_codex":[0.9997472,0.00004442345,0.0000340611,0.00005538995,0.00008045536,0.00003847394],"domain_scores_gemma":[0.999712,0.0001225956,0.00003325041,0.00001214916,0.00006403166,0.00005594099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008483324,0.0001871065,0.1400598,0.0003403038,0.00002919348,0.0173889,0.0003445305,0.000405838,0.7742534,0.0005551836,0.001600976,0.06398652],"study_design_scores_gemma":[0.00007898145,0.001583468,0.1563589,0.0001446305,0.0001611924,0.0677078,0.0009827868,0.01614497,0.7374847,0.001736401,0.01754054,0.00007564062],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8991779,0.008114412,0.07104343,0.001493737,0.0003449151,0.0008789755,0.0006651039,0.0009408921,0.01734057],"genre_scores_gemma":[0.9656886,0.001994689,0.0295239,0.000577661,0.00009753689,0.00009788931,0.0003597062,0.00003252233,0.00162747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009651809,"threshold_uncertainty_score":0.003228843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0124690878344989,"score_gpt":0.3152388464944301,"score_spread":0.3027697586599312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}