{"id":"W2336977282","doi":"10.1038/mp.2016.34","title":"Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects","year":2016,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Addiction and Mental Health","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Center for PTSD, U.S. Department of Veterans Affairs; National Institutes of Health; Servier; Bristol-Myers Squibb","keywords":"Glutamate receptor; Pharmacology; Antidepressant; Glutamine; Ketamine; Chemistry; In vivo; Metabolite; NMDA receptor; Ex vivo; Medicine; Endocrinology; Hippocampus; Anesthesia; Biology; Biochemistry; In vitro; Amino acid; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008353777,0.0003042714,0.0005385307,0.0002784602,0.0001431807,0.0002626389,0.000198133,0.0002826443,0.001553578],"category_scores_gemma":[0.0001727571,0.0001718523,0.0003173669,0.0001729198,0.0003060484,0.000263936,0.0001803297,0.0008171931,0.0002303771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004279611,"about_ca_system_score_gemma":0.0003122322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001201773,"about_ca_topic_score_gemma":0.002917483,"domain_scores_codex":[0.9999304,0.000005527321,0.000005302489,0.00001342681,0.00001407981,0.00003133346],"domain_scores_gemma":[0.9998744,0.00001261044,0.00003861938,0.00001589417,0.00001752154,0.00004095687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002768059,0.00005813487,0.00117705,0.00005344696,0.00002520842,0.0002886044,0.00003240442,0.00002908012,0.9933332,0.0001312292,0.00008363729,0.002019967],"study_design_scores_gemma":[0.0001194811,0.001655861,0.05515485,0.00001530557,0.00007312123,0.0009585356,0.0001562902,0.0007419425,0.9398432,0.0003404261,0.0009257885,0.00001519246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965867,0.001343083,0.0008573438,0.0001097071,0.00004151816,0.00001512981,0.0003552732,0.00005001932,0.0006413057],"genre_scores_gemma":[0.9974989,0.0004640262,0.0004977477,0.00006134532,0.00001900297,0.0000274866,0.0003653302,0.00001178397,0.001054346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553578,"threshold_uncertainty_score":0.005197167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01379732196665851,"score_gpt":0.2820257005663611,"score_spread":0.2682283785997026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}