{"id":"W2336997490","doi":"10.1158/1535-7163.targ-15-c185","title":"Abstract C185: Targeting PARP and DNA as a novel unimolecular combination model for the enhancement of chemosensitivity","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Olaparib; Synthetic lethality; DNA repair; Poly ADP ribose polymerase; Biology; Cancer research; DNA damage; PARP inhibitor; Programmed cell death; DNA; Polymerase; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156169,0.0003496349,0.0003276811,0.0003284975,0.0001189446,0.0003852346,0.0005287746,0.0004473831,0.002922531],"category_scores_gemma":[0.00009026653,0.0001486147,0.0002863142,0.0002312741,0.0002204176,0.000344058,0.0002578058,0.000596782,0.0004955992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004230709,"about_ca_system_score_gemma":0.0001953438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003126009,"about_ca_topic_score_gemma":0.000267285,"domain_scores_codex":[0.9998856,0.00001596404,0.000005456354,0.0000359631,0.00003369752,0.0000232435],"domain_scores_gemma":[0.9999437,0.000008921217,0.0000180617,0.000007005951,0.000005711419,0.00001645202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005114634,0.0003461351,0.0001030924,0.0001792549,0.00003266492,0.0001797727,0.0000118766,0.003806807,0.9768466,0.004499609,0.0008104549,0.01267223],"study_design_scores_gemma":[0.0002326959,0.003001276,0.0005540024,0.00001307979,0.00005153039,0.0002843168,0.000007173686,0.02675343,0.9539719,0.001100257,0.01400407,0.00002632789],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8918736,0.006944285,0.07250311,0.001023894,0.0005268154,0.0005391899,0.0008272382,0.0007438742,0.02501801],"genre_scores_gemma":[0.979936,0.001136827,0.01216794,0.0001742472,0.000038529,0.0001544403,0.000177868,0.00003120888,0.006182922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002922531,"threshold_uncertainty_score":0.009776831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07282148049106738,"score_gpt":0.3465300539674201,"score_spread":0.2737085734763527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}