{"id":"W2337030302","doi":"10.1371/journal.pone.0153017","title":"Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene Expression","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Diabète Québec; Université de Montréal; Canadian Diabetes Association","keywords":"Endocrinology; Internal medicine; AMPK; Protein kinase A; Carbohydrate metabolism; Insulin; Lipid metabolism; Biology; Pancreatic islets; Metabolism; Glucose uptake; Islet; Chemistry; Kinase; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000292211,0.0008528917,0.0004628003,0.00144838,0.000251931,0.0005956423,0.0002652126,0.0004152374,0.002063194],"category_scores_gemma":[0.0001175782,0.0004895908,0.0004713471,0.0007588063,0.000479929,0.0003566934,0.0004001128,0.001342052,0.0004474301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002656684,"about_ca_system_score_gemma":0.0001940432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003012418,"about_ca_topic_score_gemma":0.00047336,"domain_scores_codex":[0.9997161,0.00002926668,0.00004739084,0.00009652115,0.00005765235,0.00005293162],"domain_scores_gemma":[0.999658,0.00002282959,0.0001441364,0.00003752716,0.0000179,0.0001195288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008659023,0.0000955181,0.0006488981,0.00004277643,0.00001043466,0.00005737285,0.00002334365,0.0000199842,0.9972319,0.00004633588,0.00001950057,0.0009379536],"study_design_scores_gemma":[0.0002795159,0.002304233,0.1268108,0.00006513511,0.0001796928,0.002061117,0.0002434573,0.0009165534,0.8624922,0.0002871578,0.004325531,0.00003450615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945586,0.00121437,0.001880276,0.00008691677,0.00003013884,0.00004372888,0.00137162,0.0001105759,0.0007037366],"genre_scores_gemma":[0.9799979,0.002301072,0.006796551,0.0002344556,0.00003078992,0.0003105037,0.003434728,0.0001870456,0.006706842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002063194,"threshold_uncertainty_score":0.006902039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02586330722981191,"score_gpt":0.2325005356139912,"score_spread":0.2066372283841793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}