{"id":"W2337033889","doi":"10.1038/srep20842","title":"IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":213,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"U.S. Department of Health and Human Services; National Institutes of Health; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Defense Advanced Research Projects Agency","keywords":"IGHV@; Somatic hypermutation; Biology; Germline; Genetics; Allele; Genotype; Evolutionary biology; Gene; Antibody; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176672,0.0001181491,0.000141741,0.0002359481,0.0001590515,0.0002741905,0.0001091855,0.0001994108,0.001365845],"category_scores_gemma":[0.0004646752,0.00009757405,0.0001146078,0.0002241871,0.0001656593,0.0001524399,0.0001245768,0.0002152076,0.0002322418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008557232,"about_ca_system_score_gemma":0.00007021013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011824,"about_ca_topic_score_gemma":0.001097528,"domain_scores_codex":[0.9998283,0.00004222144,0.0000123928,0.00005183796,0.00002561891,0.00003949642],"domain_scores_gemma":[0.9997535,0.00005007286,0.0001013952,0.00003008482,0.00002394979,0.00004090629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008079942,0.00008540499,0.8407916,0.00003453646,0.0001158699,0.0001700643,0.0002787309,0.0001665464,0.1480505,0.0001077277,0.0002015588,0.009189536],"study_design_scores_gemma":[0.000002176676,0.0001313354,0.9959708,0.000002883088,0.00001986209,0.0002804038,0.00009608988,0.0001377696,0.00305087,0.00002755968,0.0002780182,0.00000217143],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993809,0.0001399946,0.00005959948,0.00001006143,0.000001812942,0.000001634349,0.00009202759,0.000001997933,0.000311845],"genre_scores_gemma":[0.9995885,0.0000666937,0.00002902885,0.00001470777,0.000002909005,0.000002269831,0.00008464921,0.00000249431,0.0002087265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365845,"threshold_uncertainty_score":0.004569173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05323241786357956,"score_gpt":0.3431159191506553,"score_spread":0.2898835012870757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}