{"id":"W2337065797","doi":"10.1371/journal.pone.0131269","title":"Elongation Factor 1A-1 Is a Mediator of Hepatocyte Lipotoxicity Partly through Its Canonical Function in Protein Synthesis","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Robarts Research Institute; Canadian Institutes of Health Research; University of Toronto","keywords":"Lipotoxicity; Unfolded protein response; Hepatocyte; Cell biology; Elongation factor; Biology; Programmed cell death; Internal medicine; Endocrinology; Apoptosis; Biochemistry; Endoplasmic reticulum; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416745,0.0005304736,0.0002765531,0.0001954286,0.0001753801,0.0002422691,0.0001111889,0.000219932,0.0007428862],"category_scores_gemma":[0.00008401053,0.0001407578,0.0002271211,0.0001590204,0.0001602598,0.0001741,0.0001658462,0.0003781167,0.0002416432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577099,"about_ca_system_score_gemma":0.000152874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005835259,"about_ca_topic_score_gemma":0.0006130534,"domain_scores_codex":[0.9999291,0.00001196447,0.000007649217,0.00002389999,0.00001153687,0.00001589805],"domain_scores_gemma":[0.9999363,0.000007221462,0.00002474206,0.0000060337,0.00001062006,0.00001494961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006771731,0.00002394881,0.00114242,0.0001250549,0.0000148632,0.0001612801,0.00001349412,0.0000881339,0.9940625,0.00009710515,0.00008895765,0.003505263],"study_design_scores_gemma":[0.0000584601,0.0006817846,0.02866177,0.0000332252,0.00005077319,0.0007862091,0.00005002265,0.0006105059,0.9602469,0.0001557506,0.008652144,0.000012423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9402235,0.05123856,0.005068991,0.0003481498,0.0001395834,0.00003965223,0.0009132401,0.0001347576,0.001893691],"genre_scores_gemma":[0.987269,0.008047897,0.001140756,0.00006232133,0.00002910451,0.00003227868,0.0009566831,0.00001124197,0.002450684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007428862,"threshold_uncertainty_score":0.002595425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05900352285714322,"score_gpt":0.2501832471801265,"score_spread":0.1911797243229833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}