{"id":"W2337101924","doi":"10.1177/1087057115623264","title":"A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5","year":2015,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"","keywords":"Demethylase; RNA; AlkB; Methyltransferase; RNA splicing; Biology; Biochemistry; N6-Methyladenosine; Translation (biology); Messenger RNA; Cell biology; Gene; Epigenetics; Methylation; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001624879,0.002516737,0.001224575,0.003117682,0.001349183,0.0008517526,0.002444503,0.00175575,0.005820407],"category_scores_gemma":[0.00132029,0.001675615,0.001367597,0.002047567,0.0009809867,0.0005897821,0.001309073,0.003157935,0.004711332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00157433,"about_ca_system_score_gemma":0.001841909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00278348,"about_ca_topic_score_gemma":0.01148106,"domain_scores_codex":[0.9977995,0.00062677,0.00009943329,0.000542826,0.0006543044,0.0002771263],"domain_scores_gemma":[0.9987279,0.0004197324,0.00009763888,0.0002058861,0.0003148665,0.0002339777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000230904,0.0001803645,0.0008257033,0.0001155941,0.00009524609,0.00005068236,0.00006905354,0.0002444701,0.990794,0.0004828782,0.0005255711,0.006385623],"study_design_scores_gemma":[0.00006698159,0.0006221994,0.002011626,0.00001907152,0.00009807552,0.0001933098,0.0000353045,0.003440429,0.9865745,0.0002176305,0.006694428,0.0000263819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.302132,0.005672732,0.6607079,0.0006690409,0.000381816,0.001742839,0.004356147,0.005333991,0.01900349],"genre_scores_gemma":[0.3779651,0.00282392,0.5319438,0.000501117,0.000131064,0.002565151,0.02609434,0.0006823778,0.05729306],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.005820407,"threshold_uncertainty_score":0.01947117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06560372466739793,"score_gpt":0.3224573364937885,"score_spread":0.2568536118263906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}