{"id":"W2337242297","doi":"10.1158/1538-8514.tumang15-b15","title":"Abstract B15: In vivo analysis of repeated siRNA silencing on protein expression levels","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Gene silencing; In vivo; Small interfering RNA; RNA interference; Survivin; Cancer research; Angiogenesis; Biology; Cell growth; In vitro; Cell; Cancer; Cell culture; RNA; Transfection; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002875485,0.0004427917,0.0002948663,0.0004017632,0.0002089967,0.0003009986,0.0002700522,0.0005217007,0.003600435],"category_scores_gemma":[0.0001134691,0.0001577154,0.0003887424,0.0002762819,0.000248254,0.000215024,0.0001142461,0.0008710573,0.001081842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003310425,"about_ca_system_score_gemma":0.000243011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001137561,"about_ca_topic_score_gemma":0.001028955,"domain_scores_codex":[0.9997717,0.00002602003,0.00002241677,0.00007486057,0.00006003708,0.0000450536],"domain_scores_gemma":[0.9997988,0.00004990821,0.00004634979,0.00002518526,0.00003636833,0.00004343464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000126941,0.00006737211,0.00003579229,0.00002108881,0.000004979668,0.00002532425,0.000008680083,0.00002277949,0.9988054,0.000036019,0.0000836592,0.0007619688],"study_design_scores_gemma":[0.00001578289,0.0007121642,0.00175116,0.000003173789,0.00001580019,0.0001189688,0.000008269731,0.000431873,0.9959332,0.0000195889,0.0009859813,0.000004015689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606848,0.003795127,0.02246138,0.0003173894,0.000328906,0.0002599941,0.003114673,0.0006202679,0.008417385],"genre_scores_gemma":[0.9479668,0.002269599,0.01753767,0.0002910038,0.00005160202,0.00049494,0.005136958,0.0002213339,0.02603009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003600435,"threshold_uncertainty_score":0.01204473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05033842109054801,"score_gpt":0.3123472714087568,"score_spread":0.2620088503182088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}