{"id":"W2337295026","doi":"10.1021/acs.joc.5b02569","title":"Structures of Nahuoic Acids B–E Produced in Culture by a <i>Streptomyces</i> sp. Isolated from a Marine Sediment and Evidence for the Inhibition of the Histone Methyl Transferase SETD8 in Human Cancer Cells by Nahuoic Acid A","year":2016,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Institut National Du Cancer; Centre National de la Recherche Scientifique; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale","keywords":"Chemistry; Streptomyces; Transferase; Sediment; Histone; Stereochemistry; Biochemistry; Enzyme; Bacteria; Gene; Genetics; Geology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006340999,0.0003354414,0.0001198287,0.0004522402,0.0001361312,0.0001893744,0.0001505192,0.0002017907,0.0007419381],"category_scores_gemma":[0.0001323494,0.00008172434,0.0001613142,0.0004420069,0.0001280064,0.0001393905,0.0001395859,0.0002888746,0.0002201678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001406257,"about_ca_system_score_gemma":0.0002409014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006575054,"about_ca_topic_score_gemma":0.0005935803,"domain_scores_codex":[0.9999391,0.00001167363,0.00000870822,0.00001206539,0.00001221643,0.00001633181],"domain_scores_gemma":[0.9998767,0.00001712337,0.00003381276,0.0000118457,0.00002046444,0.00003994308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005575881,0.00005603262,0.0007834853,0.00006049667,0.00001488251,0.0004164008,0.00003230852,0.000550278,0.9914546,0.0002371115,0.00005264606,0.005784071],"study_design_scores_gemma":[0.00004329309,0.00101156,0.006622348,0.00001635073,0.00003139997,0.00034336,0.0000833509,0.0007119128,0.9869126,0.0001674984,0.004042597,0.00001376818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883307,0.002575926,0.003638474,0.00007211003,0.00003642813,0.00007181896,0.001392864,0.0000325061,0.003849226],"genre_scores_gemma":[0.992269,0.001681925,0.003214292,0.00003972871,0.00001466508,0.00003082995,0.00158153,0.000008065745,0.001159906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007419381,"threshold_uncertainty_score":0.002481997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008775631972366233,"score_gpt":0.2672940697409347,"score_spread":0.2585184377685684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}