{"id":"W2337362558","doi":"10.1111/bph.13500","title":"A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant‐negative mutation of the <i>KCNE1</i> gene","year":2016,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Montreal Heart Institute","funders":"European Social Fund; Canadian Institutes of Health Research; Nemzeti Kutatási és Technológiai Hivatal; Magyar Tudományos Akadémia; Hungarian Scientific Research Fund; Nemzeti Fejlesztési Ügynökség; European Commission","keywords":"hERG; Dofetilide; QT interval; Repolarization; Cardiology; Long QT syndrome; Internal medicine; Medicine; Short QT syndrome; Ventricular action potential; Sudden cardiac death; Proarrhythmia; Potassium channel; Pharmacology; Electrophysiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004187178,0.0008322785,0.0005271774,0.0005588569,0.0002578043,0.0003544519,0.0003682193,0.0007580807,0.001491606],"category_scores_gemma":[0.0003888069,0.0002827907,0.0005611307,0.0002294514,0.0007959703,0.0004012417,0.0003138471,0.0006469418,0.0006537564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003141443,"about_ca_system_score_gemma":0.0002116701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003891004,"about_ca_topic_score_gemma":0.000459545,"domain_scores_codex":[0.9996785,0.00005085636,0.00006202888,0.0001093429,0.00005515822,0.00004407177],"domain_scores_gemma":[0.999629,0.00004909412,0.0001792062,0.00006404705,0.0000215997,0.00005704498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004303864,0.0001255506,0.0009073595,0.00004731098,0.00001953692,0.001697767,0.00007146144,0.00006044488,0.9949496,0.0003084499,0.0001085685,0.001273491],"study_design_scores_gemma":[0.001066211,0.01674813,0.05704592,0.0001266742,0.0006782072,0.08902891,0.0004443963,0.006296962,0.8139524,0.0009681231,0.01353708,0.0001068493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895488,0.0006267502,0.007375847,0.0004018859,0.00009037204,0.0001070943,0.0003956992,0.0002372962,0.001216281],"genre_scores_gemma":[0.9914369,0.0006095492,0.004651672,0.0001827723,0.00003797324,0.0001422808,0.0006135703,0.00005525401,0.002269998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491606,"threshold_uncertainty_score":0.004989922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019187972501366,"score_gpt":0.2631476838972868,"score_spread":0.2529558041722731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}