{"id":"W2337378675","doi":"10.2174/1567205013666160310144100","title":"Protein Structural Analysis of Calbindin D<sub>28k</sub> Function and Dysregulation: Potential Competition Between Ca<sup>2+</sup> and Zn<sup>2+</sup>","year":2016,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Calcium; Calbindin; Calcium-binding protein; Chemistry; Calcium metabolism; Homeostasis; Biophysics; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002088407,0.0003168248,0.0005360336,0.001381135,0.0004228753,0.0002959326,0.0005978391,0.0001415854,0.00006931621],"category_scores_gemma":[0.0001769084,0.000256296,0.000178736,0.002129881,0.0005354562,0.001110851,0.0008387546,0.0004205616,0.000026244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001096768,"about_ca_system_score_gemma":0.000201872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007024951,"about_ca_topic_score_gemma":0.00000803291,"domain_scores_codex":[0.9946489,0.00139141,0.0006549671,0.001018729,0.001647056,0.0006389191],"domain_scores_gemma":[0.9974316,0.0007727232,0.0001963325,0.0006473902,0.0006403578,0.0003116459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0003084958,0.0002264491,0.02961379,0.0002066215,0.003432476,0.0000120923,0.00229828,0.06934594,0.007962144,0.04025161,0.0004376492,0.8459045],"study_design_scores_gemma":[0.001275343,0.0002690775,0.1608687,0.0001587772,0.0006494778,0.000008324684,0.00009653982,0.8145761,0.004478277,0.01691554,0.0002519634,0.0004518473],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.84734,0.001256315,0.1496057,0.000807478,0.0001000743,0.0007021655,0.0001064915,0.00005556504,0.00002617573],"genre_scores_gemma":[0.9972076,0.00003740527,0.002230885,0.000007258458,0.0002688343,0.00006221722,0.0001476307,0.00002166843,0.00001654337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8454526,"threshold_uncertainty_score":0.9999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08532110448669256,"score_gpt":0.3723482045882533,"score_spread":0.2870271001015607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}