{"id":"W2337424844","doi":"10.1371/journal.pone.0128587","title":"A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McMaster University; University of Manitoba","funders":"Canadian Institutes of Health Research; Cystic Fibrosis Canada; Manitoba Health Research Council","keywords":"Burkholderia cenocepacia; Burkholderia cepacia complex; Microbiology; In vivo; Antibiotics; Antibacterial activity; Minimum inhibitory concentration; Bacteria; Burkholderia; Biology; Antibiotic resistance; In vitro; Chemistry; Biochemistry; Biotechnology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009144146,0.001599237,0.001627535,0.002471085,0.0006287498,0.001350199,0.0008532705,0.0007534813,0.004942221],"category_scores_gemma":[0.001238918,0.0006303489,0.001233326,0.00143638,0.0003008951,0.0007434351,0.0008379627,0.0008554151,0.002665951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005219568,"about_ca_system_score_gemma":0.002192809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001260807,"about_ca_topic_score_gemma":0.002561452,"domain_scores_codex":[0.999419,0.00006268515,0.00004759217,0.0001155412,0.0003023344,0.00005296344],"domain_scores_gemma":[0.9995233,0.0001128259,0.00007525236,0.00007587021,0.0001466512,0.00006606028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001103604,0.0005821803,0.002559646,0.00206246,0.0002651778,0.0006092586,0.00009052773,0.003311064,0.8443483,0.001141653,0.009242277,0.1346838],"study_design_scores_gemma":[0.0006947758,0.005027562,0.01165245,0.0002608418,0.000765483,0.003147676,0.0001180421,0.02119961,0.8337713,0.001726529,0.1214512,0.0001844016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3448064,0.02351422,0.3443813,0.003632699,0.0005134076,0.01094886,0.1945991,0.05349969,0.02410434],"genre_scores_gemma":[0.3404867,0.01650492,0.4504568,0.001150763,0.0001070345,0.004476539,0.1687399,0.0008272807,0.01725004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004942221,"threshold_uncertainty_score":0.01653332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1037535042174713,"score_gpt":0.2844937100539148,"score_spread":0.1807402058364435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}