{"id":"W2337446880","doi":"10.1186/s12879-016-1476-4","title":"Development and evaluation of a novel fast broad-range 16S ribosomal DNA PCR and sequencing assay for diagnosis of bacterial infective endocarditis: multi-year experience in a large Canadian healthcare zone and a literature review","year":2016,"lang":"en","type":"review","venue":"BMC Infectious Diseases","topic":"Infective Endocarditis Diagnosis and Management","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"Calgary Laboratory Services; University of Calgary","keywords":"Medical microbiology; Parasitology; 16S ribosomal RNA; Ribosomal DNA; Infective endocarditis; DNA sequencing; Ribosomal RNA; Biology; Microbiology; Medicine; Pathology; DNA; Internal medicine; Genetics; Gene; Phylogenetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003763316,0.0006256185,0.0007887329,0.004208076,0.0008027569,0.001476098,0.001183045,0.0008240141,0.0004729987],"category_scores_gemma":[0.005186337,0.0003249959,0.0005279611,0.005156307,0.001198392,0.0009291919,0.0004868832,0.0003958755,0.0001579078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003410404,"about_ca_system_score_gemma":0.01079016,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1696634,"about_ca_topic_score_gemma":0.2972962,"domain_scores_codex":[0.997707,0.000294699,0.0005022805,0.0003163077,0.001007151,0.0001725429],"domain_scores_gemma":[0.9949023,0.001053951,0.001016304,0.0001011539,0.002705025,0.0002212372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0003783907,0.0002896448,0.3154782,0.02092341,0.0004967315,0.01509162,0.006206869,0.0005285593,0.020837,0.0004086489,0.003938632,0.6154222],"study_design_scores_gemma":[0.00008362872,0.001172137,0.7980321,0.01065678,0.002889073,0.06382201,0.01340145,0.001470918,0.01121975,0.000265168,0.09671268,0.0002742391],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2481331,0.743388,0.002534823,0.001546277,0.0002531225,0.0002219327,0.0002982099,0.00003881004,0.003585786],"genre_scores_gemma":[0.4277054,0.5600632,0.009026444,0.001362691,0.0002811948,0.00009580576,0.0006481982,0.00002070262,0.0007964235],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8303366,"threshold_uncertainty_score":0.3373516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07418113689517655,"score_gpt":0.3674686460964477,"score_spread":0.2932875092012711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}