{"id":"W2337538391","doi":"10.1038/onc.2015.377","title":"PIK3CAH1047R- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling","year":2015,"lang":"en","type":"article","venue":"Oncogene","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"National Cancer Institute","keywords":"Biology; MAPK/ERK pathway; PI3K/AKT/mTOR pathway; Cancer research; Dependency (UML); Cell biology; Signal transduction; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003406923,0.000197524,0.0002325555,0.00005130775,0.00005128612,0.0000197417,0.0002127675,0.0001930632,0.00002703175],"category_scores_gemma":[0.00009787005,0.0002089956,0.00005854121,0.0001141383,0.0000873719,0.00001319609,0.0001194596,0.0001078434,0.000005330409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004725401,"about_ca_system_score_gemma":0.0002534644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006656733,"about_ca_topic_score_gemma":0.000009332163,"domain_scores_codex":[0.9986993,0.0001153374,0.0003073676,0.0003855485,0.0002576321,0.0002348095],"domain_scores_gemma":[0.9990858,0.0000275658,0.0001984242,0.0003185725,0.0002079486,0.0001617288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001068561,0.00006458227,0.001808414,0.00002890536,0.00006953468,0.000005745323,0.00006632166,0.00009234538,0.993152,0.00002825662,0.002479956,0.002097076],"study_design_scores_gemma":[0.0009159124,0.0003915263,0.0002221253,0.00005312368,0.0000261748,0.00002091353,0.00009326531,0.0001201635,0.9925028,0.0001717427,0.005229334,0.0002529293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916834,0.002958812,0.003161375,0.00008373162,0.0001506879,0.0001628295,0.0000391379,0.00002596614,0.001734087],"genre_scores_gemma":[0.9974462,0.0001033996,0.001574766,0.0002656197,0.0001677706,0.00001662313,0.0002120952,0.00003763093,0.0001759315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005762791,"threshold_uncertainty_score":0.8522593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02668500361734861,"score_gpt":0.2706221272548395,"score_spread":0.2439371236374909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}