{"id":"W2337828519","doi":"10.1186/s12888-016-0785-x","title":"Discovering biomarkers for antidepressant response: protocol from the Canadian biomarker integration network in depression (CAN-BIND) and clinical characteristics of the first patient cohort","year":2016,"lang":"en","type":"article","venue":"BMC Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Baycrest Hospital; St. Michael's Hospital; University of Calgary; McMaster University; Indoc Research; St. Joseph’s Healthcare Hamilton; Royal Ottawa Mental Health Centre; McGill University; Simon Fraser University; University of Ottawa; University of Toronto; University Health Network; Queen's University; University of British Columbia; University of Guelph; Centre for Addiction and Mental Health; Vancouver Coastal Health","funders":"Daiichi Sankyo Europe; Servier; University of Toronto; H. Lundbeck A/S; J.P. Bickell Foundation; National Institutes of Health; Canadian Network for Mood and Anxiety Treatments; Centre for Addiction and Mental Health; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation; Sunovion; Ontario Brain Institute; Pfizer; Government of Ontario; BrainsWay; National Alliance for Research on Schizophrenia and Depression; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; Hamilton Health Sciences Foundation; Campbell Institute; Hamilton Health Sciences","keywords":"Major depressive disorder; Antidepressant; Biomarker; Medicine; Aripiprazole; Neurocognitive; Clinical trial; Neuroimaging; Escitalopram; Psychiatry; Oncology; Depression (economics); Bioinformatics; Clinical psychology; Psychology; Internal medicine; Mood; Cognition; Schizophrenia (object-oriented programming); Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02004096,0.002083933,0.002186906,0.002169959,0.006015656,0.002312793,0.003280132,0.002310419,0.01778974],"category_scores_gemma":[0.0260492,0.001348074,0.001962183,0.004097551,0.00166472,0.001153869,0.00208944,0.001978476,0.00423001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02675036,"about_ca_system_score_gemma":0.06660891,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3470208,"about_ca_topic_score_gemma":0.5169212,"domain_scores_codex":[0.9909757,0.003189442,0.001306417,0.001313648,0.002000638,0.001214181],"domain_scores_gemma":[0.9787202,0.002037307,0.002392951,0.002529825,0.01110648,0.003213143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1581091,0.01097119,0.1707973,0.00692939,0.002024746,0.001144749,0.003103956,0.009232254,0.00468488,0.009185279,0.485959,0.1378582],"study_design_scores_gemma":[0.09045824,0.01124245,0.5330026,0.00326252,0.001215159,0.0004832231,0.001328705,0.004236118,0.002233156,0.004080929,0.3477433,0.0007135828],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.02364233,0.0007244469,0.004712356,0.001468397,0.0003379604,0.8691902,0.09107494,0.0001366286,0.008712735],"genre_scores_gemma":[0.02922777,0.0004949161,0.01062463,0.001298225,0.0001760137,0.9234286,0.03238699,0.00003504501,0.002327775],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.6529793,"threshold_uncertainty_score":0.6900018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02298023322398549,"score_gpt":0.3077820489244178,"score_spread":0.2848018157004323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}