{"id":"W2338087590","doi":"10.1089/jir.2015.0134","title":"Lipopolysaccharide-Mediated Induction of Concurrent IL-1β and IL-23 Expression in THP-1 Cells Exhibits Differential Requirements for Caspase-1 and Cathepsin B Activity","year":2016,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inflammasome; Cell biology; Pyrin domain; Cathepsin; TLR4; Biology; Lipopolysaccharide; Caspase 1; Innate immune system; Interleukin; Interleukin 10; Toll-like receptor; Signal transduction; Receptor; Chemistry; Inflammation; Cytokine; Immunology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002618917,0.000598239,0.0005292534,0.0002871636,0.0001997619,0.0005145395,0.0001574217,0.0003076542,0.001645383],"category_scores_gemma":[0.0001647266,0.0002008704,0.0005516091,0.000370088,0.000336918,0.0003082331,0.0002674053,0.001062413,0.0008636675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603139,"about_ca_system_score_gemma":0.0002607986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002977114,"about_ca_topic_score_gemma":0.0004625608,"domain_scores_codex":[0.9995849,0.00007199327,0.00004926586,0.00005949084,0.0001056078,0.0001288917],"domain_scores_gemma":[0.999747,0.00004589037,0.0000662016,0.00004115127,0.00003816401,0.00006168831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001255425,0.00002029447,0.00006884636,0.00004556225,0.000003514251,0.00009990469,0.00002265513,0.00002616692,0.9992549,0.00003526457,0.00002721975,0.0002699836],"study_design_scores_gemma":[0.00002889096,0.0003752196,0.005296052,0.00001499695,0.00001975831,0.0005317487,0.00008437882,0.0004345366,0.9903997,0.00007658047,0.002723696,0.00001447577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823118,0.005291442,0.006146558,0.0003081987,0.0001805616,0.0001562945,0.003410325,0.0001321662,0.002062591],"genre_scores_gemma":[0.9877551,0.001935114,0.005791561,0.0001873454,0.00005805084,0.0002115278,0.002269861,0.00003319703,0.001758268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001645383,"threshold_uncertainty_score":0.00550437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04602880081018277,"score_gpt":0.3414810162660496,"score_spread":0.2954522154558668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}