{"id":"W2338087590","doi":"10.1089/jir.2015.0134","title":"Lipopolysaccharide-Mediated Induction of Concurrent IL-1β and IL-23 Expression in THP-1 Cells Exhibits Differential Requirements for Caspase-1 and Cathepsin B Activity","year":2016,"lang":"en","type":"article","venue":"Journal of Interferon & Cytokine Research","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inflammasome; Cell biology; Pyrin domain; Cathepsin; TLR4; Biology; Lipopolysaccharide; Caspase 1; Innate immune system; Interleukin; Interleukin 10; Toll-like receptor; Signal transduction; Receptor; Chemistry; Inflammation; Cytokine; Immunology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007848208,0.0001313097,0.0002487515,0.0002534399,0.00005253962,0.0000210306,0.0001473269,0.0001409012,0.00001394101],"category_scores_gemma":[0.0002789593,0.00008882568,0.00006990635,0.00006436102,0.0001677033,0.00003457496,0.0001869565,0.0002192063,8.428361e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004705661,"about_ca_system_score_gemma":0.00009316311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003066671,"about_ca_topic_score_gemma":0.00003890433,"domain_scores_codex":[0.9986214,0.0001941679,0.0004118566,0.0002136158,0.0002772838,0.0002816921],"domain_scores_gemma":[0.9990671,0.00008427034,0.0002444931,0.0001482767,0.0003706816,0.00008517478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001743395,0.0001607949,0.000914958,0.00006024514,0.00004066268,0.000002439724,0.0001340848,5.268251e-7,0.9818932,0.000004480833,0.0005589639,0.01448618],"study_design_scores_gemma":[0.002524661,0.002345036,0.00251139,0.0003162416,0.000009827269,0.00001272063,0.0001891952,0.00001923003,0.9912539,0.00003069311,0.0006913181,0.00009584799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978952,0.0004296215,0.0008934347,0.0002626404,0.0002054217,0.0002469638,0.00005358719,0.000001345528,0.00001181928],"genre_scores_gemma":[0.9979138,0.001770845,0.00002989534,0.000005431079,0.0001369708,0.00001144238,0.000008864487,0.00001577368,0.0001069531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01439033,"threshold_uncertainty_score":0.3622206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04602880081018277,"score_gpt":0.3414810162660496,"score_spread":0.2954522154558668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}