{"id":"W2338104793","doi":"10.1055/s-0037-1616149","title":"Selective and Sustained Inhibition of Surface-bound Thrombin Activity by Intimatan/Heparin Cofactor II and Its Relevance to Assessing Systemic Anticoagulation In Vivo, Ex Vivo and In Vitro","year":2001,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Kingston University; Heart and Stroke Foundation of Canada","keywords":"Thrombin; In vivo; Thrombogenicity; Heparin; Heparin cofactor II; Chemistry; In vitro; Ex vivo; Discovery and development of direct thrombin inhibitors; Pharmacology; Biochemistry; Platelet; Medicine; Internal medicine; Antithrombin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005789718,0.0003190466,0.0003548811,0.0002289201,0.00009349664,0.0003584354,0.0001618321,0.0001883693,0.0007080305],"category_scores_gemma":[0.0005516601,0.0001275689,0.0001333282,0.000181165,0.0002554966,0.0001857238,0.0001204941,0.0004661259,0.0001689824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122795,"about_ca_system_score_gemma":0.0002325819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004866143,"about_ca_topic_score_gemma":0.000582672,"domain_scores_codex":[0.9996852,0.000110851,0.00002127985,0.00004175104,0.00009533031,0.00004558739],"domain_scores_gemma":[0.9997578,0.00008116067,0.00006101414,0.00003396635,0.00002798593,0.00003805596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004094217,0.0000560824,0.001533056,0.00004317155,0.00001469967,0.00003632754,0.00001594211,0.00007530867,0.992311,0.00005741986,0.00001835697,0.005429293],"study_design_scores_gemma":[0.00002457038,0.001637104,0.01257918,0.000004223213,0.00003405785,0.0002958302,0.0000171623,0.001284105,0.98365,0.00003596564,0.0004343816,0.000003448902],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883258,0.00495964,0.005603349,0.00003035987,0.000014861,0.00001677271,0.00005719728,0.00002849996,0.0009634963],"genre_scores_gemma":[0.9932523,0.001187379,0.004483206,0.00002082049,0.00002473079,0.00002475646,0.0001823382,0.000007454224,0.0008169783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007080305,"threshold_uncertainty_score":0.00306195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04159525473268783,"score_gpt":0.318447973523817,"score_spread":0.2768527187911292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}