{"id":"W2338105231","doi":"10.1038/onc.2016.122","title":"ERK1/2-induced phosphorylation of R-Ras GTPases stimulates their oncogenic potential","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Canada Research Chairs","keywords":"GTPase; Biology; Phosphorylation; Ras superfamily; Serine; Cell biology; Kinase; Mutant; Signal transducing adaptor protein; Biochemistry; GTP'; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688831,0.0001589759,0.0001663787,0.00005086257,0.00006023165,0.000008767109,0.0001330061,0.0001523083,0.0001457588],"category_scores_gemma":[0.00007622802,0.0001122564,0.0001525348,0.00008684954,0.00005743534,0.000006330381,0.00006671609,0.00003200191,0.00001682928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002099605,"about_ca_system_score_gemma":0.00009533658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001266733,"about_ca_topic_score_gemma":0.000008711956,"domain_scores_codex":[0.999027,0.00005728133,0.0002714145,0.0002978934,0.0001503348,0.0001960897],"domain_scores_gemma":[0.9992797,0.00001619479,0.0001556237,0.0003298139,0.0001387328,0.00007988184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001308786,0.00005271136,0.0003586596,0.000008113234,0.00005460517,0.00000231529,0.00001072733,0.0001053184,0.9641495,0.00008364391,0.0001082321,0.03493535],"study_design_scores_gemma":[0.0008861867,0.0002279442,0.0009598624,0.00003271563,0.00002395644,0.000009798273,0.00001280375,0.000110614,0.9920717,0.0001929327,0.005299826,0.0001717003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899001,0.001063063,0.008228992,0.0001898201,0.0001260948,0.0001849487,0.00004522509,0.00001991911,0.0002418717],"genre_scores_gemma":[0.9985494,0.00009688237,0.0005918152,0.00006144845,0.0002335358,0.00001324687,0.00006688495,0.00002506989,0.0003617129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03476365,"threshold_uncertainty_score":0.4577684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01343240874716449,"score_gpt":0.244094420581947,"score_spread":0.2306620118347825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}