{"id":"W2338181945","doi":"10.1038/ncomms11127","title":"mTORC1 and CK2 coordinate ternary and eIF4F complex assembly","year":2016,"lang":"en","type":"article","venue":"Nature Communications","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Princess Margaret Cancer Centre; Western University; McGill University; University of Toronto; Jewish General Hospital","funders":"Cancerföreningen i Stockholm; Vetenskapsrådet; Barncancerfonden; Cancerfonden; Swedish Foundation for International Cooperation in Research and Higher Education; Canadian Institutes of Health Research; Cancer Research Society; Faculty of Medicine, McGill University; McGill University","keywords":"mTORC1; Phosphorylation; eIF2; Integrated stress response; Translation (biology); Cell biology; PI3K/AKT/mTOR pathway; Eukaryotic translation; Ternary complex; Biology; Signal transduction; Biochemistry; Messenger RNA; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003369648,0.0005586834,0.0005148076,0.0005429537,0.0004111679,0.001016921,0.0003838725,0.0003774252,0.001594733],"category_scores_gemma":[0.0003473395,0.000270515,0.000293865,0.0003130423,0.000313789,0.0005057433,0.0007284214,0.0005799808,0.0005271444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001161369,"about_ca_system_score_gemma":0.0007655611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001602807,"about_ca_topic_score_gemma":0.003612143,"domain_scores_codex":[0.9996743,0.00003378004,0.00003250807,0.00007377049,0.0000835251,0.0001020411],"domain_scores_gemma":[0.9998366,0.00001284012,0.00004055515,0.00001686143,0.00004085994,0.00005230094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009231914,0.00007324253,0.001650534,0.0002698319,0.00002801213,0.0002377201,0.00005665592,0.0008335278,0.9777997,0.002929254,0.001105817,0.01409255],"study_design_scores_gemma":[0.00007289351,0.0002063238,0.01833509,0.00002317027,0.00003709926,0.0003984505,0.00007902056,0.00525414,0.9599362,0.000897577,0.01473438,0.00002564483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9515451,0.01458405,0.01626028,0.000991662,0.0004868897,0.0001135473,0.00108842,0.0008850274,0.01404518],"genre_scores_gemma":[0.9883853,0.001524471,0.005136854,0.0001163949,0.00008043089,0.00005941097,0.00049855,0.00005681602,0.004141681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001602807,"threshold_uncertainty_score":0.008426368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098281040557386,"score_gpt":0.3107711188926309,"score_spread":0.289788308487057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}