{"id":"W2338202961","doi":"10.1128/iai.01426-15","title":"CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria <i>In Vivo</i>","year":2016,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Government of Canada","keywords":"CD47; Biology; Phagocytosis; Parasitemia; Macrophage; Plasmodium falciparum; Innate immune system; Plasmodium berghei; Immune system; Immunology; In vivo; Cell biology; In vitro; Malaria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247563,0.0002594267,0.0002121328,0.0001423914,0.0001453069,0.0003988945,0.0001578504,0.000253936,0.0009710903],"category_scores_gemma":[0.00009807779,0.0002021826,0.000194275,0.0001149704,0.0003173914,0.0002199565,0.0001841693,0.0005845847,0.0005025539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003826817,"about_ca_system_score_gemma":0.0001816014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004102513,"about_ca_topic_score_gemma":0.0005931754,"domain_scores_codex":[0.999841,0.00002900322,0.00001309543,0.00003147063,0.00003138802,0.00005404987],"domain_scores_gemma":[0.9998704,0.00001133169,0.0000578761,0.000008840791,0.00001086255,0.00004061454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003382883,0.00003124631,0.0004369827,0.00002318444,0.000003463987,0.00003956524,0.00001198551,0.00005472754,0.9983367,0.00009858476,0.0000494842,0.0005758422],"study_design_scores_gemma":[0.00004341906,0.0002212053,0.01657732,0.000007575332,0.0000173175,0.0002418976,0.00005326865,0.001992381,0.9791275,0.00005489751,0.00165861,0.000004686804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963185,0.0009691998,0.001322882,0.00008728764,0.00001190518,0.00001427195,0.0003039458,0.00005409083,0.0009179333],"genre_scores_gemma":[0.9965615,0.0006536797,0.000947256,0.00005129476,0.000007187185,0.00003008274,0.0003852445,0.00002016219,0.001343767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009710903,"threshold_uncertainty_score":0.003248572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335599476799408,"score_gpt":0.2469640311587192,"score_spread":0.2336080363907251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}