{"id":"W2338242379","doi":"10.1016/j.pediatrneurol.2016.03.008","title":"A Prospective Case Study of the Safety and Efficacy of Lysine-Restricted Diet and Arginine Supplementation Therapy in a Patient With Pyridoxine-Dependent Epilepsy Caused by Mutations in ALDH7A1","year":2016,"lang":"en","type":"article","venue":"Pediatric Neurology","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Pyridoxine; Arginine; Epilepsy; Medicine; Lysine; Prospective cohort study; Pharmacology; Internal medicine; Gastroenterology; Endocrinology; Biochemistry; Chemistry; Amino acid; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005806828,0.0005637642,0.0007477661,0.0007092492,0.001609272,0.0009548804,0.0004925388,0.001547828,0.002080141],"category_scores_gemma":[0.002695401,0.0004830005,0.0009385658,0.0006202579,0.0009681184,0.0007220615,0.0005914575,0.001216364,0.0004806923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007026453,"about_ca_system_score_gemma":0.0006754146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002486313,"about_ca_topic_score_gemma":0.001657336,"domain_scores_codex":[0.9993605,0.0001236967,0.0001099187,0.000215697,0.0000833967,0.0001067679],"domain_scores_gemma":[0.9979076,0.0007160476,0.0004723143,0.0002428397,0.0001945745,0.0004665544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"case_report","study_design_scores_codex":[0.002980962,0.00346345,0.7634659,0.00008012277,0.0002979717,0.2173653,0.00137504,0.0001771864,0.003106043,0.0002418522,0.0002974377,0.007148692],"study_design_scores_gemma":[0.000569528,0.01342187,0.5050436,0.00005824313,0.0005563678,0.4722863,0.002237824,0.001115719,0.001880088,0.0003405089,0.002331775,0.0001582621],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985684,0.0003468966,0.0001556028,0.00009398544,0.00001331207,0.00002511122,0.00005047291,0.000003782574,0.0007425001],"genre_scores_gemma":[0.9990634,0.0001802656,0.0001388983,0.0001135655,0.00004538237,0.0000120284,0.0001145364,0.000005306023,0.0003266117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002486313,"threshold_uncertainty_score":0.006958783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004549833032488867,"score_gpt":0.2290232175689826,"score_spread":0.2244733845364937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}