{"id":"W2338292049","doi":"10.1200/jco.2013.31.15_suppl.tps4161","title":"Phase IIb randomized trial of Pexa-Vec (pexastimogene devacirepvec; JX-594), a targeted oncolytic vaccinia virus, plus best supportive care (BSC) versus BSC alone in patients with advanced hepatocellular carcinoma who have failed sorafenib treatment (TRAVERSE).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Sorafenib; Oncolytic virus; Hepatocellular carcinoma; Hazard ratio; Internal medicine; Oncology; Randomized controlled trial; Gastroenterology; Cancer; Surgery; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002065348,0.002794734,0.003106984,0.0004704267,0.0004180932,0.001373858,0.0009927565,0.002112003,0.0106149],"category_scores_gemma":[0.001793986,0.0008690117,0.001725946,0.0004791661,0.001235125,0.001398897,0.0005136551,0.003519843,0.001781757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001131362,"about_ca_system_score_gemma":0.001067919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00136891,"about_ca_topic_score_gemma":0.003022058,"domain_scores_codex":[0.9994426,0.0003020591,0.00002188625,0.00009894702,0.00003102844,0.0001035015],"domain_scores_gemma":[0.999084,0.0002048064,0.0002087974,0.00007545156,0.00004999735,0.0003769931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9837233,0.004309018,0.0004048419,0.0002971267,0.0004772089,0.00003005418,0.00003557404,0.0003216871,0.001920889,0.0001309374,0.001313679,0.007035718],"study_design_scores_gemma":[0.9466311,0.05075806,0.0009270806,0.00001918019,0.0002250697,0.00002913753,0.00002044416,0.0003629591,0.0002161386,0.0001929564,0.0006070323,0.00001090145],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775625,0.003883831,0.0009243621,0.002070637,0.001454249,0.006344392,0.002991316,0.0002843923,0.004484294],"genre_scores_gemma":[0.9713798,0.002328569,0.002001459,0.002751769,0.0008358964,0.008524757,0.003734976,0.00006041018,0.008382238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0106149,"threshold_uncertainty_score":0.03551036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04530350708514023,"score_gpt":0.3894889658126659,"score_spread":0.3441854587275257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}