{"id":"W2338301901","doi":"10.1016/s0026-895x(24)26455-5","title":"High-Affinity Binding of Peptide Agonists to the Human B1 Bradykinin Receptor Depends on Interaction between the Peptide N-Terminal l-Lysine and the Fourth Extracellular Domain of the Receptor","year":2000,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institute of General Medical Sciences","keywords":"Peptide; Receptor; Chemistry; Kallidin; Bradykinin receptor; Agonist; Bradykinin; Enzyme-linked receptor; Protease-activated receptor 2; Transmembrane domain; C-terminus; Biochemistry; Stereochemistry; Kinin; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002602758,0.0003118502,0.0003178404,0.0001836166,0.000343824,0.0003944007,0.0003029396,0.000382287,0.002801625],"category_scores_gemma":[0.0004184844,0.0002714583,0.0002506564,0.000138752,0.0002635176,0.000278448,0.0003629454,0.0005428254,0.001555255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004065487,"about_ca_system_score_gemma":0.0002148093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000873629,"about_ca_topic_score_gemma":0.001751051,"domain_scores_codex":[0.9997024,0.00007310958,0.00001110686,0.00002866501,0.00006582143,0.0001188958],"domain_scores_gemma":[0.999764,0.0001215995,0.00002657194,0.00002142759,0.00002190022,0.00004446455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003639337,0.00006427218,0.0004144335,0.00004784057,0.00001053188,0.0001759929,0.0000380469,0.00007325163,0.9961111,0.0002124838,0.0001524126,0.002335643],"study_design_scores_gemma":[0.0001894391,0.0008010244,0.03332118,0.00002591515,0.00003199661,0.00240584,0.00008269763,0.001764613,0.9553664,0.0002383538,0.005746061,0.00002644121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818994,0.003963811,0.004510329,0.0002650299,0.00005034967,0.00008738174,0.0001256997,0.00005281141,0.00904514],"genre_scores_gemma":[0.988272,0.001817772,0.002605148,0.0002507847,0.00005285571,0.00005471983,0.0005509346,0.00001757622,0.006378229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002801625,"threshold_uncertainty_score":0.009372354,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541448645209999,"score_gpt":0.2912403522401479,"score_spread":0.2758258657880479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}