{"id":"W2338301901","doi":"10.1016/s0026-895x(24)26455-5","title":"High-Affinity Binding of Peptide Agonists to the Human B1 Bradykinin Receptor Depends on Interaction between the Peptide N-Terminal l-Lysine and the Fourth Extracellular Domain of the Receptor","year":2000,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Purdue Pharma (Canada)","funders":"National Institute of General Medical Sciences","keywords":"Peptide; Receptor; Chemistry; Kallidin; Bradykinin receptor; Agonist; Bradykinin; Enzyme-linked receptor; Protease-activated receptor 2; Transmembrane domain; C-terminus; Biochemistry; Stereochemistry; Kinin; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001137769,0.0002930067,0.0005423101,0.0001107195,0.0004746937,0.0000291225,0.0004657846,0.0001204487,0.001111015],"category_scores_gemma":[0.00009415671,0.000150761,0.0002872102,0.00039845,0.00057648,0.00006051099,0.0001374309,0.0005063859,0.00003854721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007601417,"about_ca_system_score_gemma":0.00007518886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002550578,"about_ca_topic_score_gemma":0.00003404361,"domain_scores_codex":[0.9972878,0.000878276,0.000663984,0.0003783837,0.0004294152,0.0003621392],"domain_scores_gemma":[0.9982797,0.0005795712,0.0003932646,0.0005354127,0.00009981509,0.0001122655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002564407,0.0004161646,0.01124947,0.0001043273,0.0009656784,0.00004556584,0.004312829,0.0006467706,0.9392206,0.002432514,0.0102625,0.02777916],"study_design_scores_gemma":[0.008307818,0.001002369,0.05267085,0.0002675923,0.001332948,0.0001470126,0.0004952532,0.0002460778,0.8528747,0.0004258197,0.0818305,0.0003990557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832956,0.0003665834,0.0001201908,0.01420279,0.0004340067,0.001060259,0.00003750991,0.00002649621,0.0004565277],"genre_scores_gemma":[0.9962489,0.00006388353,0.0002313135,0.001298231,0.000495785,0.00006612844,0.00004935569,0.0000420826,0.001504311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08634592,"threshold_uncertainty_score":0.9998021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541448645209999,"score_gpt":0.2912403522401479,"score_spread":0.2758258657880479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}