{"id":"W2338302780","doi":"10.1038/srep15182","title":"Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"National Cancer Institute; Prostate Cancer Foundation","keywords":"Prostate cancer; PTEN; Cancer research; Enzalutamide; Medicine; LNCaP; Gene knockdown; Prostate; Androgen deprivation therapy; Cancer; Biochemical recurrence; PI3K/AKT/mTOR pathway; Biology; Internal medicine; Signal transduction; Androgen receptor; Cell culture; Prostatectomy; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001607362,0.00008870088,0.0001761838,0.00008604606,0.0001344772,0.00003620641,0.00004210687,0.00003983527,0.00003519694],"category_scores_gemma":[0.000166625,0.00005433266,0.00007206807,0.0005194097,0.000290855,0.00009009805,0.0000466062,0.00008968814,0.000001082951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001724535,"about_ca_system_score_gemma":0.0007198841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003381707,"about_ca_topic_score_gemma":0.00003238481,"domain_scores_codex":[0.9980071,0.00005387295,0.0005057734,0.0003299877,0.0008884532,0.0002147929],"domain_scores_gemma":[0.9984728,0.00001405213,0.0004105701,0.0003451289,0.0006544951,0.0001029438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001520485,0.0000932306,0.01726115,0.0001394712,0.00002901797,0.00005532409,0.002290855,0.0002145269,0.9618844,0.000005329135,0.01749348,0.0003811441],"study_design_scores_gemma":[0.0005050912,0.0001130055,0.0008714193,0.0003241251,0.0000641869,0.00002339613,0.001024481,0.0001197959,0.9937159,0.0004074927,0.002766354,0.00006474558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953158,0.002048353,0.00001099046,0.0004008703,0.0009527755,0.0006320603,0.00004306155,0.00001310894,0.000582955],"genre_scores_gemma":[0.9969121,0.00001261165,0.0001092759,0.000008316862,0.00002517626,0.00003249671,0.0001675322,0.000009414358,0.002723057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03183149,"threshold_uncertainty_score":0.2215622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04047699441204022,"score_gpt":0.31637565235398,"score_spread":0.2758986579419398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}