{"id":"W2338302780","doi":"10.1038/srep15182","title":"Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"National Cancer Institute; Prostate Cancer Foundation","keywords":"Prostate cancer; PTEN; Cancer research; Enzalutamide; Medicine; LNCaP; Gene knockdown; Prostate; Androgen deprivation therapy; Cancer; Biochemical recurrence; PI3K/AKT/mTOR pathway; Biology; Internal medicine; Signal transduction; Androgen receptor; Cell culture; Prostatectomy; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001441038,0.0004676371,0.0002632579,0.0003717937,0.0001635578,0.0003636187,0.0001747758,0.0001273078,0.001039449],"category_scores_gemma":[0.00006229542,0.0001271327,0.0003011525,0.0002433182,0.0002260036,0.0001286224,0.0001870743,0.0005950145,0.0002148535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003061806,"about_ca_system_score_gemma":0.0004012974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006583353,"about_ca_topic_score_gemma":0.002396917,"domain_scores_codex":[0.9998869,0.0000136977,0.000009301291,0.00001465487,0.00004688757,0.00002865223],"domain_scores_gemma":[0.9999653,0.000005143878,0.000009476164,0.000003582307,0.000002849964,0.00001364555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008870019,0.00007836369,0.0001573715,0.00005067947,0.00001090136,0.00005553221,0.000009267053,0.0002256707,0.9963716,0.0001828296,0.0001212408,0.002647798],"study_design_scores_gemma":[0.00002208424,0.0006863207,0.002887802,0.000003302724,0.00002030532,0.0002448258,0.00001347597,0.001095265,0.9922358,0.00006755453,0.002717399,0.00000574243],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877247,0.002824949,0.003944462,0.0001785183,0.0000774424,0.00009241122,0.000854548,0.0002365506,0.004066335],"genre_scores_gemma":[0.9921812,0.00160797,0.002684803,0.00004440203,0.000013726,0.00005201015,0.0006212425,0.00001801606,0.00277672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001039449,"threshold_uncertainty_score":0.003477275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04047699441204022,"score_gpt":0.31637565235398,"score_spread":0.2758986579419398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}