{"id":"W2338308476","doi":"10.1074/jbc.m115.695809","title":"Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages","year":2016,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"HDAC8; Biology; Kinase; Histone deacetylase; MAPK/ERK pathway; Immune system; Small interfering RNA; Protein kinase A; Cell biology; Molecular biology; Histone; Microbiology; Cell culture; Biochemistry; Immunology; Transfection; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004964725,0.0002131901,0.000374586,0.00004028099,0.00003751067,0.00001374676,0.0001607611,0.0004711525,0.0005919617],"category_scores_gemma":[0.0003105569,0.0001373652,0.0001875789,0.00009805743,0.0002834026,0.00001705012,0.0001472388,0.0002630395,0.000004471287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009683501,"about_ca_system_score_gemma":0.00005714989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009638025,"about_ca_topic_score_gemma":0.000001005686,"domain_scores_codex":[0.9983143,0.000110707,0.0006909026,0.0003295612,0.0002494222,0.0003050903],"domain_scores_gemma":[0.9989581,0.00004690604,0.0004360818,0.0002053238,0.000188838,0.0001647963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001203859,0.0002939733,0.0002616716,0.00005592273,0.00001708949,0.00004596476,0.00001909547,3.106426e-7,0.9771709,5.249177e-7,0.01883564,0.002095059],"study_design_scores_gemma":[0.002153246,0.0006577263,0.0001791554,0.0002452269,0.000006280075,0.00007974757,0.00004680993,9.334091e-7,0.9899012,0.00004994769,0.006500161,0.0001795033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974216,0.001186794,0.0003497381,0.0004171053,0.00005250887,0.00009047567,0.0001797011,0.000004489925,0.0002975352],"genre_scores_gemma":[0.99735,0.001516154,0.0001240009,0.00009555435,0.0002295739,0.000005862915,0.00009481358,0.00001445641,0.0005695888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01273038,"threshold_uncertainty_score":0.6481565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322019354425483,"score_gpt":0.2697410487945595,"score_spread":0.2565208552503047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}