{"id":"W2338408404","doi":"10.1016/j.atherosclerosis.2016.04.011","title":"Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution","year":2016,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; Fondation Leducq; European Commission; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; British Heart Foundation; Massachusetts General Hospital","keywords":"Genome-wide association study; Computational biology; Biology; Genetics; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004097897,0.0004296393,0.0004135538,0.0009668483,0.0003739992,0.0004628243,0.0002066107,0.0005197434,0.001794748],"category_scores_gemma":[0.001177942,0.0002473038,0.0005347609,0.0008605443,0.000195682,0.0001087882,0.0002703193,0.0004064258,0.0004285596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001926899,"about_ca_system_score_gemma":0.0002513387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153753,"about_ca_topic_score_gemma":0.003367166,"domain_scores_codex":[0.999524,0.0001200065,0.00005987219,0.0001525613,0.00007709481,0.0000665867],"domain_scores_gemma":[0.9993649,0.0003278269,0.0001211252,0.00006429049,0.00005950515,0.00006234594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004059624,0.0002352767,0.161467,0.0001968478,0.0004687361,0.005498295,0.00103456,0.002202848,0.7889582,0.001507013,0.001016653,0.03335493],"study_design_scores_gemma":[0.0003487905,0.0006025556,0.8203042,0.0001630778,0.0009871856,0.01252573,0.0003562986,0.009579439,0.145765,0.00183266,0.007475591,0.00005950142],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861215,0.0003375403,0.01019904,0.00009958061,0.00002473685,0.00004307379,0.002093851,0.00007915172,0.001001533],"genre_scores_gemma":[0.992057,0.0001216326,0.005461423,0.0001876581,0.00001464521,0.00003308971,0.001177641,0.0000413464,0.0009055214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001794748,"threshold_uncertainty_score":0.006004035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01979678321521556,"score_gpt":0.2270250556233876,"score_spread":0.207228272408172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}