{"id":"W2338464704","doi":"10.1182/blood.v122.21.3085.3085","title":"Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"RNA splicing; Alternative splicing; Stromal cell; Splicing factor; Downregulation and upregulation; Cancer research; Biology; Exon; Gene expression; Cell culture; Molecular biology; Bone marrow; RNA; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442306,0.0001752746,0.0002431431,0.0001886907,0.0001686185,0.0002802674,0.00009355773,0.0001856336,0.001565946],"category_scores_gemma":[0.00008122563,0.0001163997,0.0002304028,0.0001887096,0.0001239634,0.0000875,0.0002057379,0.0004681538,0.0002550521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857138,"about_ca_system_score_gemma":0.0001373315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007370727,"about_ca_topic_score_gemma":0.001028338,"domain_scores_codex":[0.9998822,0.00001781914,0.000008208111,0.00002208843,0.00003961017,0.00003011866],"domain_scores_gemma":[0.999952,0.000006867997,0.00001491283,0.000004225283,0.000008796936,0.00001328029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002298643,0.00002468243,0.001983379,0.00003773731,0.0000120545,0.00008102841,0.00002188866,0.00004272076,0.9963046,0.00004210708,0.0001243949,0.001095595],"study_design_scores_gemma":[0.00008515962,0.0009217465,0.199244,0.00002591061,0.00009999683,0.0007492785,0.0003225305,0.002346735,0.7875032,0.0002677759,0.008418009,0.00001566012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941798,0.002686069,0.001220168,0.000171115,0.00003740103,0.00001693771,0.0008978196,0.00006536144,0.0007251908],"genre_scores_gemma":[0.9961061,0.0008852007,0.0005827937,0.0001354705,0.00001076634,0.00003473011,0.000717667,0.00001197245,0.00151524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001565946,"threshold_uncertainty_score":0.005238593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.018447345420321,"score_gpt":0.2535769200385018,"score_spread":0.2351295746181808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}