{"id":"W2338479504","doi":"10.1021/acs.biochem.5b00691","title":"Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Deprotonation; Chemistry; Lanthanide; Bioinorganic chemistry; Metal; Substrate (aquarium); Metal ions in aqueous solution; Ribozyme; Cleavage (geology); Enzyme; Stereochemistry; RNA; DNA; Biochemistry; Ion; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001201884,0.0001792565,0.0001804049,0.00002432649,0.00002867621,0.00001840218,0.0001107638,0.0001989296,0.000001119104],"category_scores_gemma":[0.00003963211,0.0001472558,0.00004060719,0.00008988044,0.0001776447,0.000005362156,0.00007398826,0.00007276739,5.138104e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001331554,"about_ca_system_score_gemma":0.0000790731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001311231,"about_ca_topic_score_gemma":0.000002638801,"domain_scores_codex":[0.9990921,0.00001542731,0.0002046466,0.0003439139,0.0001665641,0.0001773445],"domain_scores_gemma":[0.9992931,0.000004199804,0.0001433842,0.0002706818,0.000162995,0.0001255931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002487391,0.00005719282,0.002126422,0.00002990392,0.00004269449,0.000004007722,0.00001327168,7.2936e-7,0.9971275,0.000007424439,0.00008827943,0.000253812],"study_design_scores_gemma":[0.0004374064,0.0001738841,0.0004446559,0.00003013465,0.00003354115,0.00005713593,0.00006753871,0.00003492198,0.9983478,0.00001124274,0.0001541104,0.0002076416],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984674,0.0002171455,0.0007069688,0.00005660454,0.00001544291,0.00008429355,0.00005105783,0.00003268855,0.0003683923],"genre_scores_gemma":[0.9977065,0.00009667892,0.001323348,0.00004800917,0.00009190497,0.000007579727,0.0004279794,0.00001801453,0.0002799568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001681766,"threshold_uncertainty_score":0.6004915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009947721630697078,"score_gpt":0.2373235629838726,"score_spread":0.2273758413531756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}