{"id":"W2338479504","doi":"10.1021/acs.biochem.5b00691","title":"Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Deprotonation; Chemistry; Lanthanide; Bioinorganic chemistry; Metal; Substrate (aquarium); Metal ions in aqueous solution; Ribozyme; Cleavage (geology); Enzyme; Stereochemistry; RNA; DNA; Biochemistry; Ion; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003611715,0.0005328727,0.0006537181,0.0002180892,0.0000886753,0.0004447423,0.0003404333,0.0004136133,0.0004555388],"category_scores_gemma":[0.0008124664,0.0002052404,0.0004566675,0.0003497129,0.0002321948,0.0001990442,0.0002620216,0.000525547,0.0005670265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002538517,"about_ca_system_score_gemma":0.0002208267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004268599,"about_ca_topic_score_gemma":0.0004084263,"domain_scores_codex":[0.9996523,0.00006300747,0.00004904557,0.00008606353,0.0001087793,0.00004073969],"domain_scores_gemma":[0.999397,0.0001718979,0.0001253719,0.00006826847,0.0001264951,0.0001109299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001712396,0.000007592178,0.0001089049,0.0000185346,0.000004237912,0.00001829796,0.000006003055,0.00003449588,0.9992536,0.00001352569,0.000002694022,0.0005149954],"study_design_scores_gemma":[0.000002710669,0.00005836902,0.001246564,0.000002425772,0.000006404304,0.0001691799,0.000007589866,0.0003087221,0.9977288,0.00001170954,0.0004542361,0.000003293253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713796,0.001582974,0.02547357,0.00007760681,0.00002182701,0.000100166,0.0004138835,0.0001394309,0.0008110871],"genre_scores_gemma":[0.9547305,0.001035613,0.03795866,0.00006655373,0.00001104511,0.0001393447,0.002014224,0.000133263,0.00391087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006537181,"threshold_uncertainty_score":0.00191009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009947721630697078,"score_gpt":0.2373235629838726,"score_spread":0.2273758413531756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}