{"id":"W2338494814","doi":"10.1001/jama.2016.4059","title":"Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma","year":2016,"lang":"en","type":"article","venue":"JAMA","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1062,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Ipilimumab; Pembrolizumab; Internal medicine; Melanoma; Oncology; Clinical endpoint; Clinical trial; Cohort; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002208993,0.0002134664,0.0004567182,0.0003634754,0.0002173056,0.0003483222,0.0002101474,0.0004956446,0.001162544],"category_scores_gemma":[0.003648264,0.0001571015,0.0005427915,0.0003713215,0.0001805628,0.0004498852,0.0002538634,0.0006653547,0.0001376814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002617527,"about_ca_system_score_gemma":0.000242506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003565924,"about_ca_topic_score_gemma":0.0006321559,"domain_scores_codex":[0.9990681,0.0003930362,0.00008911243,0.0002091945,0.0001560356,0.00008456206],"domain_scores_gemma":[0.996856,0.001112616,0.001346318,0.0001760785,0.0002057934,0.0003032595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01391197,0.0004646652,0.9701034,0.00009523981,0.0006497682,0.00004379212,0.00004911445,0.0004330596,0.001273449,0.00002927521,0.0003434005,0.01260291],"study_design_scores_gemma":[0.0007721069,0.003676406,0.9929603,0.00001755857,0.0003675439,0.0002035247,0.00003366136,0.0009573085,0.0003555872,0.00005991363,0.000587592,0.000008498872],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977544,0.001425471,0.0001233575,0.00008731796,0.00001077088,0.00002292525,0.000268685,0.000004864328,0.0003021972],"genre_scores_gemma":[0.9994299,0.0001190046,0.00005691087,0.00004400874,0.00002425792,0.00001516498,0.0002007411,0.000001233123,0.0001086343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002208993,"threshold_uncertainty_score":0.01168239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004169126603923786,"score_gpt":0.2152291648597737,"score_spread":0.2110600382558499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}