{"id":"W2338494814","doi":"10.1001/jama.2016.4059","title":"Association of Pembrolizumab With Tumor Response and Survival Among Patients With Advanced Melanoma","year":2016,"lang":"en","type":"article","venue":"JAMA","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1062,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Medicine; Ipilimumab; Pembrolizumab; Internal medicine; Melanoma; Oncology; Clinical endpoint; Clinical trial; Cohort; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002037845,0.00007626929,0.0001629952,0.00004446533,0.00002250808,0.000006152574,0.00002608601,0.00003716436,0.00004699592],"category_scores_gemma":[0.000106695,0.00003924783,0.00001992443,0.00008758447,0.00006201164,0.0001073856,0.000007785242,0.00003859053,0.000001189969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001118573,"about_ca_system_score_gemma":0.00005806735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000329219,"about_ca_topic_score_gemma":0.00006184404,"domain_scores_codex":[0.9993463,0.00005739792,0.0001179969,0.0001229909,0.0002402901,0.0001150429],"domain_scores_gemma":[0.9993889,0.0001463123,0.0001525973,0.0001255006,0.0001461376,0.00004051698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09052385,0.00005786546,0.8800915,0.00001747771,0.0001226232,0.000005706669,0.0001025129,6.496965e-8,0.007527703,0.000002892064,0.0001819744,0.02136578],"study_design_scores_gemma":[0.02247303,0.001906765,0.968962,0.0002281199,0.00004185082,0.000003221136,0.0000429337,0.000001099555,0.004692279,0.000002561542,0.001576272,0.00006989023],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982867,0.0000434625,0.00001893835,0.0009910492,0.00003764572,0.0002072735,0.00002186865,0.00001579341,0.0003772182],"genre_scores_gemma":[0.99843,0.0000158941,0.0001198373,0.00009420348,0.00002129332,0.000009195484,0.000003939587,0.00001252346,0.001293184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08887044,"threshold_uncertainty_score":0.160048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004169126603923786,"score_gpt":0.2152291648597737,"score_spread":0.2110600382558499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}